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Natalie Silliman
Researcher at Howard Hughes Medical Institute
Publications - 34
Citations - 10744
Natalie Silliman is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 18, co-authored 28 publications receiving 8844 citations. Previous affiliations of Natalie Silliman include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
Journal ArticleDOI
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Joshua D. Cohen,Lu Li,Yuxuan Wang,Christopher J. Thoburn,Bahman Afsari,Ludmila Danilova,Christopher Douville,Ammar A. Javed,Fay Wong,Austin Mattox,Ralph H. Hruban,Ralph H. Hruban,Christopher L. Wolfgang,Michael Goggins,Marco Dal Molin,Tian Li Wang,Tian Li Wang,Richard B.S. Roden,Richard B.S. Roden,Alison P. Klein,Alison P. Klein,Janine Ptak,Lisa Dobbyn,Joy Schaefer,Natalie Silliman,Maria Popoli,Joshua T. Vogelstein,J.D. Browne,Robert E. Schoen,Randall E. Brand,Jeanne Tie,Peter Gibbs,Hui-Li Wong,Aaron S. Mansfield,Jin Jen,Samir M. Hanash,Massimo Falconi,Peter J. Allen,Shibin Zhou,Chetan Bettegowda,Luis A. Diaz,Cristian Tomasetti,Cristian Tomasetti,Kenneth W. Kinzler,Bert Vogelstein,Anne Marie Lennon,Nickolas Papadopoulos +46 more
TL;DR: A blood test that combines protein and DNA markers may allow earlier detection of eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA.
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Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
Jeanne Tie,Yuxuan Wang,Cristian Tomasetti,Cristian Tomasetti,Lu Li,Simeon Springer,Isaac Kinde,Natalie Silliman,Mark Tacey,Hui-Li Wong,Hui-Li Wong,Michael Christie,Michael Christie,Suzanne Kosmider,Iain Skinner,Rachel Wong,Rachel Wong,Malcolm Steel,Ben Tran,Jayesh Desai,Jayesh Desai,Ian T. Jones,Ian T. Jones,Andrew Haydon,Theresa M. Hayes,Timothy J. Price,Robert L. Strausberg,Luis A. Diaz,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Peter Gibbs +31 more
TL;DR: It is shown that the presence of circulating tumor DNA in a patient’s blood after surgery is a sign of persistent tumor and a greatly increased risk of relapse, suggesting that this group of patients may require chemotherapy to prevent recurrence.
Journal ArticleDOI
The PIK3CA gene is mutated with high frequency in human breast cancers
Kurtis E. Bachman,Pedram Argani,Yardena Samuels,Natalie Silliman,Janine Ptak,Steve Szabo,Hiroyuki Konishi,Bedri Karakas,Brian G. Blair,Clarence Lin,Brock A. Peters,Victor E. Velculescu,Ben Ho Park +12 more
TL;DR: It is shown that thirteen of fifty-three breast cancers contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain, demonstrating that Pik3CA is the most mutated oncogene in breast cancer.
Journal ArticleDOI
Colorectal cancer: mutations in a signalling pathway.
D. Williams Parsons,Tian Li Wang,Yardena Samuels,Alberto Bardelli,Alberto Bardelli,Jordan M. Cummins,Laura DeLong,Natalie Silliman,Janine Ptak,Steve Szabo,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Christoph Lengauer,Victor E. Velculescu +15 more
TL;DR: Analysis of human colorectal cancers for genetic mutations in 340 serine/threonine kinases found mutations in eight genes, including three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway, which may provide new targets for therapeutic intervention.