S
Steve W. Homans
Researcher at University of Oxford
Publications - 9
Citations - 1442
Steve W. Homans is an academic researcher from University of Oxford. The author has contributed to research in topics: Oligosaccharide & Trypanosoma brucei. The author has an hindex of 7, co-authored 9 publications receiving 1412 citations. Previous affiliations of Steve W. Homans include University of Dundee & University of Lausanne.
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Journal ArticleDOI
Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane
TL;DR: The chemical structures of the major species of G-PI anchors found on a single variant surface glycoprotein of the parasitic protozoan Trypanosoma brucei were determined by a combination of nuclear magnetic resonance spectroscopy, mass spectrometry, chemical modification, and exoglycosidase digestions.
Journal ArticleDOI
Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein.
Steve W. Homans,Michael A. J. Ferguson,Raymond A. Dwek,Thomas W. Rademacher,Rita Anand,Alan F. Williams +5 more
TL;DR: The structure of the GPI anchor of rat brain Thy-1 glycoprotein is reported, which has an identical backbone to the VSG anchor but shows significant differences in side chain moieties.
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Structures of glycosylphosphatidylinositol membrane anchors from Saccharomyces cerevisiae.
Christoph Fankhauser,Steve W. Homans,Jane Thomas-Oates,Malcolm J. McConville,Chantal Desponds,Andreas Conzelmann,Michael A. J. Ferguson +6 more
TL;DR: In this paper, yeast glycosylphosphatidylinositol membrane anchors were extracted from a crude yeast membrane protein fraction and analyzed by two-dimensional 1H-1H NMR, fast atom bombardment mass spectrometry, compositional and methylation linkage analyses, as well as chemical and enzymatic modifications.
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Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease.
Pascal Schneider,Michael A. J. Ferguson,Malcolm J. McConville,A. Mehlert,Steve W. Homans,Clément Bordier +5 more
TL;DR: The glycan structure is identical to the conserved glycan core regions of the GPI anchor of Trypanosoma brucei variant surface glycoprotein and rat brain Thy-1 antigen, supporting the notion that this portion of GPIs are highly conserved.
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Evolutionary aspects of GPI metabolism in kinetoplastid parasites.
TL;DR: The function of G PI anchors, and the origins of GPI-related molecules, primarily with reference to the protozoan parasites Trypanosoma brucei and the Leishmania are speculated on.