S
Steven L. Brody
Researcher at National Institutes of Health
Publications - 8
Citations - 1362
Steven L. Brody is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 7, co-authored 8 publications receiving 1351 citations. Previous affiliations of Steven L. Brody include Cornell University.
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Journal ArticleDOI
Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis.
Ronald G. Crystal,Noel G. McElvaney,Noel G. McElvaney,Melissa A. Rosenfeld,Chin-Shyan Chu,Andrea Mastrangeli,Andrea Mastrangeli,J. G. Hay,J. G. Hay,Steven L. Brody,H A Jaffe,N. T. Eissa,Claire Danel +12 more
TL;DR: It is feasible to use an adenovirus vector to transfer and express the CFTR cDNA in the respiratory epithelium of individuals with CF and Correction of the CF phenotype of the airway epithelia might be achieved with this strategy.
Journal ArticleDOI
Adenovirus-mediated in vivo gene transfer.
TL;DR: Using this vector, the normal human CFTR cDNA has been successfully transferred to airway epithelial cells of experimental animals via the trachea, and led to the development of human gene therapy protocols for the evaluation of the safety and efficacy of adenovirus-mediated CF TR cDNA transfer to lungs of individuals with cystic fibrosis.
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Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA.
TL;DR: Data demonstrate that AdCFTR is well tolerated in non-human primates, although there is dose-dependent inflammation in the lung not clinically apparent, and the presence of Ad CFTR DNA, analyzed by the polymerase chain reaction (PCR), was not detected in organs outside the lung.
Journal ArticleDOI
Direct In Vivo Gene Transfer and Expression in Malignant Cells Using Adenovirus Vectors
TL;DR: It is demonstrated that replication-deficient recombinant adenovirus vectors can be used to transfer genes to malignant cells in vivo and a new strategy for genetic modification for antitumor therapy is suggested.
Journal ArticleDOI
Gene therapy for the respiratory manifestations of cystic fibrosis.
Robert J. Korst,Noel G. McElvaney,Chin-Shyan Chu,Melissa A. Rosenfeld,Andrea Mastrangeli,John G. Hay,Steven L. Brody,N. Tony Eissa,Claire Danel,H. Ari Jaffe,Ronald G. Crystal +10 more
TL;DR: There is clear evidence that it is feasible to transfer and express the normal CFTR cDNA to the airway epithelium in vivo in individuals with CF.