Robert P. Wersto

TL;DR: It is shown that nestin is abundant in ES-derived progenitor cells that have the potential to develop into neuroectodermal, endodermal and mesodermal lineages and suggested that its presence in cells may indicate multi-potentiality and regenerative potential.

TL;DR: The mechanistic involvement of a unique and previously undescribed subset of regulatory B cells, designated tumor-evoked Bregs (tBreg), is reported, which suggests that tBregs must be controlled to interrupt the initiation of a key cancer-induced immunosuppressive event that is critical to support cancer metastasis.

TL;DR: Zscan4 knockdown shortens telomeres, increases karyotype abnormalities and spontaneous sister chromatid exchange, and slows down cell proliferation until reaching crisis by passage eight, which shows a unique mode of genome maintenance in ES cells.

TL;DR: The data suggest that cell cycle activation is a critical element of the DNA damage response of postmitotic neurons leading to apoptosis.

TL;DR: Defective mitotic spindle checkpoints in breast cancer are most likely not caused by low expression or mutations of these eight checkpoint genes, and increased expression of these genes might be markers of breast cancers with chromosomal instability.