Steven Lotz

TL;DR: It is shown that proliferative SVZ progenitor cells home to endothelial cells in a stromal-derived factor 1 (SDF1)- and CXC chemokine receptor 4-dependent manner and that SDF1 increases the motility of type A neuroblasts, which migrate from the SVZ toward the olfactory bulb.

TL;DR: The results indicate that exogenous IL-12 can improve innate defense in the lung against S. pneumoniae by inducing IFN-γ production, which in turn enhances chemokine expression, and promotes pulmonary neutrophil recruitment into the infected lung.

TL;DR: Analysis of pulmonary cytokine levels revealed that TLR2 deficiency results in significantly lower levels of tumor necrosis factor alpha and interleukin-6 but increased amounts of gamma interferon and monocyte chemoattractant protein 1, which may contribute to the exaggerated pathogenesis seen inTLR2−/− mice.

TL;DR: The controlled release FGF2 additive reduces the frequency of media changes needed to maintain stem cell cultures, so that human embryonic stem cells and induced pluripotent stem cells can be maintained successfully with biweekly feedings.

TL;DR: This work shows that NPTX1, a secreted protein, is rapidly upregulated during neural induction from human pluripotent stem cells (hPSCs), and identifies one of the earliest genes expressed upon neural induction and provides insight into human neural lineage specification.