Showing papers by "Steven R. Feldman published in 1991"
TL;DR: Through the study of genes involved in the development of cancer, prognosis of several malignant neoplasms are assessed and specific inhibitors of oncogene activity have potential use in treatment regimens for cancer.
Abstract: • Genes that are involved in the development of cancer have been identified. These genes, called "oncogenes," are related to normal cellular genes called "proto-oncogenes," which code for proteins involved in the regulation of cellular growth and differentiation. Through the study of these genes, we now begin to assess prognosis of several malignant neoplasms. Moreover, specific inhibitors of oncogene activity have potential use in treatment regimens for cancer. ( Arch Dermatol. 1991;127:707-711)
8 citations
TL;DR: Complementary DNA (cDNA) coding for a portion of desmoplakin-1 was obtained by screening a lambda gt11 cDNA library constructed specifically for this purpose by demonstrating that antibody affinity purified on the protein product of the clone bound desmplakins 1 and 2 in Western blots.