Showing papers in "The American Journal of the Medical Sciences in 1991"

TL;DR: Vigorous efforts at diagnosis and treatment of iron overload are essential since the pathologic effects of iron are totally preventable by early vigorous iron removal and prevention of iron re-accumulation.

TL;DR: Septic shock is the most common type of shock encountered by internists, and its prevalence appears to be increasing.

TL;DR: It is demonstrated that the expression of activated stromelysin in papilloma-derived cells enhances in vitro cell invasion and the hypothesis is that alterations in oncogenes and suppressor genes influence stamelysin expression and thus influence subsequent steps of tumor invasion and metastasis.

TL;DR: It is confirmed that breast milk is a significant source for early EBV infection of infants, as indicated by serologic studies and prospective followup of infants.

TL;DR: The data indicate that the reduced brain uptake of glucose in chronic hyperglycemia can occur in the absence of a change in glucose transporter concentration.

TL;DR: SEGF seems to play an important physiological role in the maintenance of the functional integrity of the esophageal mucosa and the mucous layer of esophagus and its permselective properties were investigated for this study.

TL;DR: This instrument provides a simple way to quantify the impact of altered fibrin structure and platelet function on clot retraction and may offer a new approach to the study of qualitative platelet dysfunction.

TL;DR: In this article, a 40-year-old woman with known von Recklinghausen neurofibromatosis presented with bone pain, multiple pseudofractures, marked increase in osteoid by bone biopsy, and hypophosphatemia with renal phosphate wasting.

TL;DR: ZnBG behaved as an in vitro photooxidizer by degrading, in the presence of cool white light, the reduced form of nicotinamide adenine dinucleotide phosphate and histidine to CO and other nonidentified products and enhanced the natural photodegradation of bilirubin.

TL;DR: Dose-intensive programs may lead to further improvements in survival of selected patients with this disease, and a multimodality approach to patients with locally advanced disease and inflammatory cancer has resulted in improved survival.

TL;DR: An increasing body of evidence supports the concept that polypeptides in the milk of several species may function physiologically.

TL;DR: The use of recombinant retroviruses for gene transfer in vivo is still a new area of research, but the feasibility of gene therapy for genetic disorders is rapidly gaining medical and scientific acceptance as mentioned in this paper.

TL;DR: It is postulate that in the latent enzyme state the conserved profragment sequence interacts with the metal atom at the active site through a sulfhydryl-metal atom coordination that is further stabilized by the amino acyl residues surrounding the essential 73Cys residue.

TL;DR: Characteristic clinical features include a high frequency of congestive heart failure and nephritis and a proclivity for aortic valve involvement, commonly with associated ring abscess, and large vegetations.

TL;DR: VLBW infants with BPD are at greater risk for poor neurodevelopmental outcome than those without BPD, and this risk relates to CNS complications rather than to chronic lung disease.

TL;DR: Three patients with right-sided hepatic hydrothorax in the absence of ascites are described, and the formation of pleural fluid in these patients is probably a result of fluid movement from peritoneal to pleural space across diaphragmatic defects before ascites can form.

TL;DR: Endocrine manifestations of HIV infection include both pathological changes and disturbances in function, which may be found at any time in the course of the disease, from the asymptomatic HIV-positive stage through full-blown AIDS.

TL;DR: It is concluded that a decrease in PaCO2 causes the observed decreases in MAP with hyperventilation, which most likely represents a direct peripheral vasodilator effect of hypocarbia rather than a reflex or centrally-mediated mechanism since the patient population is characterized by inadequate or absent autonomic cardiovascular reflex responses.

TL;DR: Analysis of ten fully documented cases of aplastic anemia associated with use of the antithyroid drugs methimazole, carbimazoles, and propylthiouracil indicated that the disorder is typically characterized by severe pancytopenia and profound marrow hypoplasia, yet surprisingly good prognosis, ie, minimum survival of more than 70% with partial or complete recovery from symptoms and cytopenias in survivors within 2-5 weeks.

TL;DR: The authors conclude that in the newborn units, the compliance with handwashing is generally poor and believe that with continued monitoring and educational efforts, it may be possible to improve habits regarding handwashing prophylaxis.

TL;DR: Characterization assays for the RNA-directed probe screening system in this monkey model of trachoma provide initial molecular evidence that ocular chlamydial infection may persist longer than previously thought, based solely on direct fluorescence antibody assay (DFA) and culture analyses.

TL;DR: Early in the course of a painful crisis, a 19-year-old man with known sickle cell anemia developed a clinical picture that resembled either early cavernous sinus thrombosis or retroorbital and bifrontal microinfarcts.

TL;DR: This study is among the first that validates descriptive data on the health problems of homeless persons by using concurrent nonhomeless controls, which may help in designing programs to meet the medical needs of the homeless.

TL;DR: This review will focus on the age-related changes in bone physiology as it relates to osteoporosis and consider the available evidence for using commonly used (calcium) or approved (estrogen and calcitonin) agents in the elderly patient.

TL;DR: While acute splenic sequestration and splenic infarction are commonly observed in infants and young children with sickle cell anemia, they are rarely experienced by adult hemoglobin S homozygotes as discussed by the authors.

TL;DR: In this article, the authors reviewed evidence for the endothelium as a regulator of regional perfusion and several of the endothelial-derived substances and their potential role in disease, including vasoactive prostaglandins, relaxing factor and endothelin.

TL;DR: Recommendations for prolonged antibiotic courses should be reconsidered in patients with negative cultures who become afebrile but remain neutropenic between 1980 and 1986.

TL;DR: The two general goals of initial therapy are to relieve hypoxemia and to reduce pulmonary capillary pressure, and a search for and specific management of the underlying cause of pulmonary edema can proceed.

TL;DR: This case emphasizes the typical slow development of microcystic adnexal carcinoma (MAC), and the implication of the association of MAC and radiotherapy are discussed.