S
Steven Timmermans
Researcher at Ghent University
Publications - 26
Citations - 548
Steven Timmermans is an academic researcher from Ghent University. The author has contributed to research in topics: Glucocorticoid receptor & Gene. The author has an hindex of 7, co-authored 21 publications receiving 236 citations. Previous affiliations of Steven Timmermans include Flanders Institute for Biotechnology.
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Journal ArticleDOI
A General Introduction to Glucocorticoid Biology.
TL;DR: A general overview on the current insights in GC biology with a focus on GC synthesis, regulation and physiology, role in inflammation inhibition, and on GR function and plasticity is provided.
Journal ArticleDOI
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
Marlies Ballegeer,Kelly Van Looveren,Steven Timmermans,Melanie Eggermont,Sofie Vandevyver,Fabien Thery,Karen Dendoncker,Jolien Souffriau,Jolien Vandewalle,Lise Van Wyngene,Riet De Rycke,Nozomi Takahashi,Peter Vandenabeele,Jan Tuckermann,Holger M. Reichardt,Francis Impens,Rudi Beyaert,Karolien De Bosscher,Roosmarijn E. Vandenbroucke,Claude Libert +19 more
TL;DR: These findings support a critical interplay among gut microbiota, IFNs, necroptosis, and GR in both the basal response to acute inflammatory challenges and pharmacological intervention by GCs.
Journal ArticleDOI
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1
Leen Puimège,Filip Van Hauwermeiren,Sophie Steeland,Sara Van Ryckeghem,Jolien Vandewalle,Sofie Lodens,Lien Dejager,Sofie Vandevyver,Jan Staelens,Steven Timmermans,Roosmarijn E. Vandenbroucke,Claude Libert +11 more
TL;DR: It is found that miR‐511 inhibits endotoxemia and experimental hepatitis and that this miR is strongly induced by glucocorticoids and is a true TNFR1 modulator and thus an anti‐inflammatory miR.
Journal ArticleDOI
TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.
Karen Dendoncker,Steven Timmermans,Jolien Vandewalle,Melanie Eggermont,Joanna K. Lempiäinen,Ville Paakinaho,Evelien Van Hamme,Sylviane Dewaele,Sofie Vandevyver,Marlies Ballegeer,Jolien Souffriau,Lise Van Wyngene,Kelly Van Looveren,Tineke Vanderhaeghen,Rudi Beyaert,Karolien De Bosscher,Jorma J. Palvimo,Marc Van Montagu,Claude Libert +18 more
TL;DR: The data suggest that selective increase of the p300 availability for GR, but not for NFκB, may prevent or revert the problem of GCR and improve the glucocorticoid therapeutic value in inflammation.
Journal ArticleDOI
Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.
Steven Timmermans,Steven Timmermans,Marc Van Montagu,Marc Van Montagu,Claude Libert,Claude Libert +5 more
TL;DR: A bioinformatics tool is developed that allows us to compare the sequences of all protein-coding genes of 36 sequenced mouse inbred strains with the reference mouse strain C57BL/6J and provide an estimate of the effect on protein function of each deviant protein sequence.