R
Roosmarijn E. Vandenbroucke
Researcher at Ghent University
Publications - 149
Citations - 8762
Roosmarijn E. Vandenbroucke is an academic researcher from Ghent University. The author has contributed to research in topics: Inflammation & Tumor necrosis factor alpha. The author has an hindex of 44, co-authored 127 publications receiving 6635 citations. Previous affiliations of Roosmarijn E. Vandenbroucke include Flanders Institute for Biotechnology.
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Journal ArticleDOI
Is there new hope for therapeutic matrix metalloproteinase inhibition
TL;DR: The recent advances made in understanding the role of MMPs in inflammatory diseases and the therapeutic potential of M Parliamentary metalloproteinases inhibition in those conditions are discussed.
Journal ArticleDOI
The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls
Dries Vercauteren,Roosmarijn E. Vandenbroucke,Arwyn Tomos Jones,Joanna Rejman,Joseph Demeester,Stefaan C. De Smedt,Niek N. Sanders,Kevin Braeckmans +7 more
TL;DR: It is found that chlorpromazine and to a lesser extent MbetaCD significantly decreased cell viability of some cell lines even after short incubation periods and at concentrations that are routinely used to inhibit endocytosis.
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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Hannah Van Hove,Liesbet Martens,Isabelle Scheyltjens,Karen De Vlaminck,Ana Rita Pombo Antunes,Sofie De Prijck,Niels Vandamme,Sebastiaan De Schepper,Gert Van Isterdael,Charlotte L. Scott,Charlotte L. Scott,Jeroen Aerts,Geert Berx,Guy E. Boeckxstaens,Roosmarijn E. Vandenbroucke,Lars Vereecke,Diederik Moechars,Martin Guilliams,Jo A. Van Ginderachter,Yvan Saeys,Kiavash Movahedi +20 more
TL;DR: The results provide a framework for understanding host–macrophage interactions in both the healthy and diseased brain and identify IRF8 as a master regulator that drives the maturation and diversity of brain macrophages.
Journal ArticleDOI
The Internalization Route Resulting in Successful Gene Expression Depends on both Cell Line and Polyethylenimine Polyplex Type
Katharina von Gersdorff,Niek N. Sanders,Roosmarijn E. Vandenbroucke,Stefaan C. De Smedt,Ernst Wagner,Manfred Ogris +5 more
TL;DR: The study revealed that the concentration window between specific inhibitory function and nonspecific toxicity of the uptake inhibitors was very narrow, and the internalization pathway mediating successful transfection depended on both cell type and polyplex type applied.
Journal ArticleDOI
Intracellularly Degradable Polyelectrolyte Microcapsules
B. G. De Geest,Roosmarijn E. Vandenbroucke,A. M. Guenther,Gleb B. Sukhorukov,Wim E. Hennink,Niek N. Sanders,Joseph Demeester,S.C. De Smedt +7 more
TL;DR: Hollow polyelectrolyte capsules are designed which, after cell entry, degrade intracellularly and could be attractive for the delivery of drugs with an intrACEllular target.