S
Stitaya Sirisinha
Researcher at Chulabhorn Research Institute
Publications - 10
Citations - 705
Stitaya Sirisinha is an academic researcher from Chulabhorn Research Institute. The author has contributed to research in topics: Burkholderia pseudomallei & Melioidosis. The author has an hindex of 9, co-authored 10 publications receiving 684 citations.
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Journal ArticleDOI
Burkholderia pseudomallei induces cell fusion and actin-associated membrane protrusion: a possible mechanism for cell-to-cell spreading.
TL;DR: Results from 4′,6′-diamidine-2-phenylindole dihydrochloride (DAPI) nuclear staining, poly-ADP ribose polymerase cleavage, staining of infected cells for phosphatidylserine exposure with annexin V, and electrophoresis of the DNA extracted from these infected cells showed that B. pseudomallei could kill the host cells by inducing apoptosis in both phagocytic and nonph
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Burkholderia pseudomallei interferes with inducible nitric oxide synthase (iNOS) production: a possible mechanism of evading macrophage killing.
P. Utaisincharoen,Nattaya Tangthawornchaikul,Wanapa Kespichayawattana,Predawan Chaisuriya,Stitaya Sirisinha +4 more
TL;DR: The results indicate that internalization of B. pseudomallei failed to trigger substantial macrophage activation, a phenomenon which could prolong their survival inside the phagocytic cells and facilitate a direct cell to cell spreading of the bacterium to neighboring cells.
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Recent developments in laboratory diagnosis of melioidosis.
Stitaya Sirisinha,Narisara Anuntagool,Tararaj Dharakul,Pattama Ekpo,Surasakdi Wongratanacheewin,Pimjai Naigowit,Benja Petchclai,Visanu Thamlikitkul,Yupin Suputtamongkol +8 more
TL;DR: A Laboratory of Immunology, Chulabhorn Research Institute, Bangkok 10210, Thailand and a Department of Microbiology, Faculty of Science, Mahidol Uni6ersity, Rama VI Road, Bangkok 10400, Thailand.
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Lipopolysaccharide from Nonvirulent Ara+ Burkholderia pseudomallei Isolates Is Immunologically Indistinguishable from Lipopolysaccharide from Virulent Ara− Clinical Isolates
Narisara Anuntagool,Pakamas Intachote,Vanaporn Wuthiekanun,Nicholas J. White,Nicholas J. White,Stitaya Sirisinha +5 more
TL;DR: In this study, lipopolysaccharides (LPSs) were extracted by the proteinase K digestion method from a total of 214 B. pseudomallei isolates, and their immunoreactivities with sera from patients with different clinical spectra and with other infections were evaluated.
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Kinetic studies of the production of nitric oxide (NO) and tumour necrosis factor-alpha (TNF-α) in macrophages stimulated with Burkholderia pseudomallei endotoxin
P. Utaisincharoen,N. Tangthawornchaikul,Wannapa Kespichayawattana,Narisara Anuntagool,P. Chaisuriya,Stitaya Sirisinha +5 more
TL;DR: It is demonstrated that the mouse macrophage cell line treated with lipopolysaccharide from B. pseudomallei produced significantly less NO and TNF‐α compared with those stimulated with the LPS from Escherichia coli and Salmonella typhi, suggesting that the unique structure of BP‐LPS exhibits a property which may interfere with macrophages' cell activation.