S
Stuart A. Newman
Researcher at New York Medical College
Publications - 198
Citations - 8470
Stuart A. Newman is an academic researcher from New York Medical College. The author has contributed to research in topics: Limb bud & Multicellular organism. The author has an hindex of 51, co-authored 194 publications receiving 7889 citations. Previous affiliations of Stuart A. Newman include Wellcome Trust Sanger Institute & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
CompuCell, a multi-model framework for simulation of morphogenesis
Jesús A. Izaguirre,R. Chaturvedi,Chengbang Huang,Trevor Cickovski,J. Coffland,Gilberto L. Thomas,Gabor Forgacs,Mark Alber,G. Hentschel,Stuart A. Newman,James A. Glazier +10 more
TL;DR: This work uses CompuCell, a multi-model software framework for simulation of the development of multicellular organisms known as morphogenesis, to simulate the formation of the skeletal architecture in the avian limb bud.
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Role of transforming growth factor-β in chondrogenic pattern formation in the embryonic limb: Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-β and evidence for endogenous TGF-β-like activity
Claire M. Leonard,Howard M. Fuld,Howard M. Fuld,Dorothy A. Frenz,Dorothy A. Frenz,Sherry A. Downie,Sherry A. Downie,Joan Massague,Stuart A. Newman,Stuart A. Newman +9 more
TL;DR: The effectiveness of a TGF-β treatment regimen in enhancing chondrogenesis was correlated with its effectiveness in stimulating condensation formation, and the “fibronectin prepattern” hypothesis for limb pattern formation was discussed.
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'Generic' physical mechanisms of morphogenesis and pattern formation.
Stuart A. Newman,W.D. Comper +1 more
TL;DR: It is proposed that such “generic” properties of embryonic tissues have played a major role in the evolution of biological form and pattern by providing an array of morphological templates, during the early stages of metazoan phylogeny, upon which natural selection could act.
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Before programs: the physical origination of multicellular forms.
TL;DR: It is shown that the expected morphologies that would arise during this relatively unconstrained "physical" stage of evolution correspond to the hollow, multilayered and segmented morphotypes seen in the gastrulation stage embryos of modern-day metazoa as well as in Ediacaran fossil deposits of approximately 600 Ma.
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Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form
Stuart A. Newman,Ramray Bhat +1 more
TL;DR: It is proposed that DPMs, acting singly and in combination with each other, constitute a "pattern language" capable of generating all metazoan body plans and organ forms, and implies that the multicellular organisms of the late Precambrian-early Cambrian were phenotypically plastic.