Subi Tharmalingam

TL;DR: The5-HTTLPR long (A/G) polymorphism influences 5-HTT density leading to higher putamen 5-htT BP in healthy L(A)/L(A) carriers of Caucasian ancestry, extending the role of this polymorphism from in vitro reports of higher 5- HTT expression into in vivo brains of healthy human subjects.

TL;DR: The results suggest a novel link between evolutionary models of seasonal weight gain on the one hand and the DRD4 gene on the other and a genetic factor that could help in the early identification and treatment of women at higher risk for seasonal weight loss associated with binge eating behavior.

TL;DR: In overeating women with SAD, the 7R allele of DRD4 may be associated with a unique developmental trajectory characterized by attentional deficits and dysphoria in childhood and mild to moderate obesity in adulthood.

TL;DR: The hypothesis that the valine allele of the Val158Met COMT polymorphism or a nearby locus is involved in the etiopathogenesis of panic disorder is supported.

TL;DR: Evidence is provided that the hypofunctional 7R allele ofDRD4 contributes to weight gain in women with BN and that the BDNF gene interacts with DRD4 to influence weight regulation in these subjects.