Sugiko Watanabe

TL;DR: Results indicate that exosome secretion maintains cellular homeostasis by removing harmful cytoplasmic DNA from cells, and provide valuable new insights into the control of cellularHomeostasis.

TL;DR: It is shown that exosome-like small EVs (sEVs) are important mediators of the pro-tumorigenic function of senescent cells, and a novel mechanism of reactive oxygen species (ROS)-regulated cargo sorting into sEVs is critical for the potentially deleterious growth-promoting effect of the senescent cell secretome.

TL;DR: The functional and regulatory network of SASPs toward opening up new possibilities for controlling aging and aging‐associated diseases are discussed.

TL;DR: It is shown that cytoplasmic accumulation of nuclear DNA plays key roles in the onset of SASP, and the blockage of this pathway prevents SASP in senescent hepatic stellate cells, accompanied by a decline of obesity-associated hepatocellular carcinoma development in mice.

TL;DR: High expression in myeloid-derived suppressor cells stimulates their chemotactic function, favouring tumour progression, and indicates that regulation of Mo-MDSCs chemotaxis is a valuable potential strategy for control of tumour development.