S
Sujeet Kumar
Researcher at Amity Institute of Biotechnology
Publications - 60
Citations - 1157
Sujeet Kumar is an academic researcher from Amity Institute of Biotechnology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 35 publications receiving 761 citations. Previous affiliations of Sujeet Kumar include University of the Sciences & Pondicherry University.
Papers
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Journal ArticleDOI
An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression
Mrinal Srivastava,Mridula Nambiar,Sheetal Sharma,Subhas S. Karki,Gunaseelan Goldsmith,Mahesh Hegde,Sujeet Kumar,Monica Pandey,Ram Kumar Singh,Pritha Ray,Renuka Natarajan,Madhura Kelkar,Abhijit De,Bibha Choudhary,Sathees C. Raghavan +14 more
TL;DR: SCR7 impedes tumor progression in mouse models and when coadministered with DSB-inducing therapeutic modalities enhances their sensitivity significantly, suggesting this inhibitor to target NHEJ offers a strategy toward the treatment of cancer and improvement of existing regimens.
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COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2.
Anshumali Mittal,Kavyashree Manjunath,Rajesh Kumar Ranjan,Sandeep Kaushik,Sujeet Kumar,Vikash Verma +5 more
TL;DR: The structure of RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 and its significance in drug discovery is discussed and the receptor recognition mechanisms of coronaviruses are explained.
Posted ContentDOI
COVID-19 Pandemic: Insights into Structure, Function, and hACE2 Receptor Recognition by the SARS-CoV-2
Anshumali Mittal,Kavyashree Manjunath,Rajesh Kumar Ranjan,Sandeep Kaushik,Sujeet Kumar,Vikash Verma +5 more
TL;DR: This review summarizes the current knowledge on the origin and evolution of SARS-CoV-2, roles of key viral factors and discuss the receptor recognition mechanisms of coronaviruses, and provides a comparative analysis of the Sars-CoVs S proteins, receptor-binding specificity, and the differences in their antigenicity based on biophysical and structural characteristics.
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Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents
Subhas S. Karki,Kuppusamy Panjamurthy,Sujeet Kumar,Mridula Nambiar,Sureshbabu A. Ramareddy,Kishore K. Chiruvella,Sathees C. Raghavan +6 more
TL;DR: FACS analysis in conjunction with mitochondrial membrane potential and DNA fragmentation studies indicated that 4a induced apoptosis without cell cycle arrest suggesting that it could be used as a potential chemotherapeutic agent.
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Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice
Mahesh Hegde,Subhas S. Karki,Elizabeth Thomas,Sujeet Kumar,Kuppusamy Panjamurthy,S. R. Ranganatha,Kanchugarakoppal S. Rangappa,Bibha Choudhary,Sathees C. Raghavan +8 more
TL;DR: 4a was found to be more potent than its parental analogue Levamisole based on both ex vivo and in vivo studies, suggesting that 4a could be used as a potent chemotherapeutic agent.