Sujie Zhu

TL;DR: In this paper, a small library of synthetic molecules and identified a potent HDAC inhibitor (HDACi), YF438, which exerts effective anti-TNBC activity both in vitro and in vivo.

TL;DR: The resulting nanogels can efficiently maintain the in vitro stability and the in vivo activity of therapeutic enzymes, facilitating the exploitation of new therapeutic enzyme formulations, which can be transported and stored in vitro for a long time and be applied effectively in vivo.

TL;DR: This work used catalase as a model protein drug to exploit a kind of chemically cross-linked nanogel that can efficiently encapsulate protein drugs and is the first use of hydrophilic nanogels as a protection niche to load protein drugs on scaffolds through an organic coating, potentially inspiring researchers to exploit new methods for protein drug loading.

TL;DR: The structure-based design of conformational constrained 4-(1-ethylsufonyl-3-indolyl)-2-phenylaminopyrimidines as new EGFRT790M/C797S inhibitors are reported by using a macrocyclization strategy to combat EGFRC797S-mediated resistance in NSCLC patients.

TL;DR: In this article , an immunity and pyroptosis-related prognostic (IPRP) signature was developed for acute myeloid leukemia (AML) patients, which consists of 15 genes.