S
Suju Mathew
Researcher at Pfizer
Publications - 6
Citations - 77
Suju Mathew is an academic researcher from Pfizer. The author has contributed to research in topics: Green chemistry metrics & Alkylation. The author has an hindex of 4, co-authored 6 publications receiving 66 citations.
Papers
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Journal ArticleDOI
Commercial Synthesis of (S,S)-Reboxetine Succinate: A Journey To Find the Cheapest Commercial Chemistry for Manufacture
Stewart T. Hayes,Georges Assaf,Graham Checksfield,Chi Cheung,Doug Critcher,Laurence James Harris,Roger M. Howard,Suju Mathew,Christian T. Regius,Gemma Scotney,Adam Scott +10 more
TL;DR: In this paper, the development of a synthetic process for (S,S)-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination.
Journal ArticleDOI
Application of a process friendly morpholine synthesis to (S,S)-Reboxetine
Georges Assaf,Gemma Cansell,Doug Critcher,Stuart Field,Stewart T. Hayes,Suju Mathew,Alan John Pettman +6 more
TL;DR: In this article, a morpholine ring system from epoxide and amino alcohol was constructed in a two-step process using a previous four-step synthesis, which was converted into a more efficient two-stage process.
Journal ArticleDOI
The use of environmental metrics to evaluate green chemistry improvements to the synthesis of ( S , S )-reboxetine succinate
Georges Assaf,Graham Checksfield,Doug Critcher,Peter J. Dunn,Stuart Field,Laurence James Harris,Roger M. Howard,Gemma Scotney,Adam Scott,Suju Mathew,Geoffrey M. H. Walker,Alexander Wilder +11 more
TL;DR: The Pfizer Green Chemistry metrics program is described and exemplified with a case history involving the synthesis of (S,S)-reboxetine succinate as mentioned in this paper, which used a classical resolution approach and generated high levels of waste.
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The Lactol Route to Fesoterodine: An Amine-Promoted Friedel–Crafts Alkylation on Commercial Scale
Olivier Dirat,Andrew J. Bibb,Colin M. Burns,Graham Checksfield,Barry Richard Dillon,Stuart Field,Steven J. Fussell,Green Stuart,Mason Clive Philip,Jinu S. Mathew,Suju Mathew,Ian B. Moses,Petar I. Nikiforov,Alan John Pettman,Flavien Susanne +14 more
TL;DR: In this paper, an amine-promoted Friedel-crafts alkylation of cinnamaldehyde with 4-hydroxymethyl phenol has been used successfully on commercial scale for the manufacture of fesoterodine, a muscarinic antagonist used for the treatment of overactive bladder.
Journal ArticleDOI
The Green Chemistry Articles of Interest
Rakeshwar Bandichhor,Apurba Bhattacharya,Louis J. Diorazio,Peter J. Dunn,Kenneth J. Fraunhoffer,Fabrice Gallou,John D. Hayler,Matthew R. Hickey,Bill Hinkley,David Hughes,Luke D. Humphreys,Bernard Kaptein,Suju Mathew,Lynnette Oh,Paul G. Richardson,Timothy D. White,Stijn Wuyts +16 more