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Showing papers by "Sunil M. Shende published in 2019"


Journal ArticleDOI
TL;DR: The in vitro bioassay data-driven profiling strategy developed in this study meets the urgent needs of computational toxicology in the current big data era and can be extended to develop predictive models for other complex toxicity end points.
Abstract: Background: Low-cost, high-throughput in vitro bioassays have potential as alternatives to animal models for toxicity testing. However, incorporating in vitro bioassays into chemical toxicity evalu...

50 citations


Posted Content
TL;DR: In this paper, the authors considered the problem of minimizing the total energy used by the robots, under the constraints that the search time is at most a multiple of the distance to the origin and the speed of the robots is bounded by a constant factor.
Abstract: Consider two robots that start at the origin of the infinite line in search of an exit at an unknown location on the line. The robots can only communicate if they arrive at the same location at exactly the same time, i.e. they use the so-called face-to-face communication model. The group search time is defined as the worst-case time as a function of $d$, the distance of the exit from the origin, when both robots can reach the exit. It has long been known that for a single robot traveling at unit speed, the search time is at least $9d-o(d)$. It was shown recently that $k\geq2$ robots traveling at unit speed also require at least $9d$ group search time. We investigate energy-time trade-offs in group search by two robots, where the energy loss experienced by a robot traveling a distance $x$ at constant speed $s$ is given by $s^2 x$. Specifically, we consider the problem of minimizing the total energy used by the robots, under the constraints that the search time is at most a multiple $c$ of the distance $d$ and the speed of the robots is bounded by $b$. Motivation for this study is that for the case when robots must complete the search in $9d$ time with maximum speed one, a single robot requires at least $9d$ energy, while for two robots, all previously proposed algorithms consume at least $28d/3$ energy. When the robots have bounded memory, we generalize existing algorithms to obtain a family of optimal (and in some cases nearly optimal) algorithms parametrized by pairs of $b,c$ values that can solve the problem for the entire spectrum of these pairs for which the problem is solvable. We also propose a novel search algorithm, with unbounded memory, that simultaneously achieves search time $9d$ and consumes energy $8.42588d$. Our result shows that two robots can search on the line in optimal time $9d$ while consuming less total energy than a single robot within the same search time.

6 citations


Proceedings ArticleDOI
21 Apr 2019
TL;DR: The result shows that two robots can search on the line in optimal time $9d$ while consuming less total energy than a single robot within the same search time.
Abstract: Consider two robots that start at the origin of the infinite line in search of an exit at an unknown location on the line. The robots can only communicate if they arrive at the same location at exactly the same time, i.e. they use the so-called face-to-face communication model. The group search time is defined as the worst-case time as a function of $d$, the distance of the exit from the origin, when both robots can reach the exit. It has long been known that for a single robot traveling at unit speed, the search time is at least $9d-o(d)$. It was shown recently that $k\geq2$ robots traveling at unit speed also require at least $9d$ group search time. We investigate energy-time trade-offs in group search by two robots, where the energy loss experienced by a robot traveling a distance $x$ at constant speed $s$ is given by $s^2 x$. Specifically, we consider the problem of minimizing the total energy used by the robots, under the constraints that the search time is at most a multiple $c$ of the distance $d$ and the speed of the robots is bounded by $b$. Motivation for this study is that for the case when robots must complete the search in $9d$ time with maximum speed one, a single robot requires at least $9d$ energy, while for two robots, all previously proposed algorithms consume at least $28d/3$ energy. When the robots have bounded memory, we generalize existing algorithms to obtain a family of optimal (and in some cases nearly optimal) algorithms parametrized by pairs of $b,c$ values that can solve the problem for the entire spectrum of these pairs for which the problem is solvable. We also propose a novel search algorithm, with unbounded memory, that simultaneously achieves search time $9d$ and consumes energy $8.42588d$. Our result shows that two robots can search on the line in optimal time $9d$ while consuming less total energy than a single robot within the same search time.

5 citations


Book ChapterDOI
01 Jul 2019
TL;DR: In this article, the authors study time-energy tradeoffs for the above evacuation problem and show that the total and makespan evacuation energies are respectively the sum and maximum of the energy consumption of the two robots while executing the evacuation algorithm.
Abstract: Two robots stand at the origin of the infinite line and are tasked with searching collaboratively for an exit at an unknown location on the line. They can travel at maximum speed b and can change speed or direction at any time. The two robots can communicate with each other at any distance and at any time. The task is completed when the last robot arrives at the exit and evacuates. We study time-energy tradeoffs for the above evacuation problem. The evacuation time is the time it takes the last robot to reach the exit. The energy it takes for a robot to travel a distance x at speed s is measured as \(xs^2\). The total and makespan evacuation energies are respectively the sum and maximum of the energy consumption of the two robots while executing the evacuation algorithm.

5 citations


Posted Content
TL;DR: Surprisingly, when $\Delta$ is a constant, independent of the distance of the exit from the origin, it is proved that evacuation is possible in time $O(d^{3/2}\log d)$, and this is optimal up to a logarithmic factor.
Abstract: Two robots stand at the origin of the infinite line and are tasked with searching collaboratively for an exit at an unknown location on the line. They can travel at maximum speed $b$ and can change speed or direction at any time. The two robots can communicate with each other at any distance and at any time. The task is completed when the last robot arrives at the exit and evacuates. We study time-energy tradeoffs for the above evacuation problem. The evacuation time is the time it takes the last robot to reach the exit. The energy it takes for a robot to travel a distance $x$ at speed $s$ is measured as $xs^2$. The total and makespan evacuation energies are respectively the sum and maximum of the energy consumption of the two robots while executing the evacuation algorithm. Assuming that the maximum speed is $b$, and the evacuation time is at most $cd$, where $d$ is the distance of the exit from the origin, we study the problem of minimizing the total energy consumption of the robots. We prove that the problem is solvable only for $bc \geq 3$. For the case $bc=3$, we give an optimal algorithm, and give upper bounds on the energy for the case $bc>3$. We also consider the problem of minimizing the evacuation time when the available energy is bounded by $\Delta$. Surprisingly, when $\Delta$ is a constant, independent of the distance $d$ of the exit from the origin, we prove that evacuation is possible in time $O(d^{3/2}\log d)$, and this is optimal up to a logarithmic factor. When $\Delta$ is linear in $d$, we give upper bounds on the evacuation time.

2 citations