S
Susan C. Laws
Researcher at United States Environmental Protection Agency
Publications - 50
Citations - 5946
Susan C. Laws is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Testosterone & Receptor. The author has an hindex of 30, co-authored 50 publications receiving 5623 citations. Previous affiliations of Susan C. Laws include Research Triangle Park.
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Journal ArticleDOI
Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist.
William R. Kelce,Stone Cr,Susan C. Laws,Leon Earl Gray,Jon A. Kemppainen,Elizabeth M. Wilson +5 more
TL;DR: It is reported that the major and persistent DDT metabolite,P,P′-DDE (l,l-dichloro-2,2-bis(P- chlorophenyl)ethylene), has little ability to bind the oestrogen receptor, but inhibits androgen binding to the androgen receptor.
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Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats.
TL;DR: In vivo studies indicated that the 3-day uterotrophic assay in prepubertal rats was the best method for detecting estrogenic activity when compared with all other end points, based upon the dose-response data for ethynyl estradiol and 4-tert-octylphenol.
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Environmental Hormone Disruptors: Evidence That Vinclozolin Developmental Toxicity Is Mediated by Antiandrogenic Metabolites
TL;DR: As the concentrations of M1 in the serum of pregnant rats and their pups on Postnatal Day 3 meet or exceed the in vitro Ki for androgen receptor inhibition, it is suggested that the demasculinizing effects of vinclozolin exposure in vivo also may be mediated via the antiandrogenic metabolites M1 and/or M2.
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Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols.
Tammy E. Stoker,Susan C. Laws,Kevin M. Crofton,Joan M. Hedge,Janet M. Ferrell,Ralph L. Cooper +5 more
TL;DR: Evidence is provided that the 31-day alternative Tier 1 male protocol is a more sensitive test protocol than the 5-day or female pubertal protocol for thyrotoxic agents that act via up-regulation of hepatic metabolism.
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The Impact of Gender and Estrogen on Striatal Dopaminergic Neurotoxicity.
TL;DR: Estrogen replacement reduced the DA, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) depletions as well as the glial fibrillary acidic protein (GFAP) elevation induced by MPTP, which indicates that estrogen has neuroprotective properties in this model of striatal dopaminergic neurotoxicity.