S
Susan E. Howlett
Researcher at Dalhousie University
Publications - 198
Citations - 7372
Susan E. Howlett is an academic researcher from Dalhousie University. The author has contributed to research in topics: Medicine & Calcium. The author has an hindex of 44, co-authored 183 publications receiving 5827 citations. Previous affiliations of Susan E. Howlett include Izaak Walton Killam Health Centre & University of Bristol.
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Journal ArticleDOI
Prevalence, Attributes, and Outcomes of Fitness and Frailty in Community-Dwelling Older Adults: Report From the Canadian Study of Health and Aging
Kenneth Rockwood,Susan E. Howlett,Chris MacKnight,B. Lynn Beattie,Howard Bergman,Réjean Hébert,David B. Hogan,Christina Wolfson,Ian McDowell +8 more
TL;DR: Fitness and frailty form a continuum and predict survival, even in old age, and are potentially useful markers of the risk for adverse health outcomes, and add value to traditional medical assessments that focus on diagnoses.
Journal ArticleDOI
Sex differences in frailty: A systematic review and meta-analysis.
TL;DR: The pattern of sex differences in the FI and mortality of older adults was consistent across populations and confirmed a ‘male‐female health‐survival paradox’.
Journal ArticleDOI
Microbial shifts in the aging mouse gut
Morgan G. I. Langille,Conor J. Meehan,Conor J. Meehan,Jeremy E. Koenig,Akhilesh S. Dhanani,Robert A. Rose,Susan E. Howlett,Robert G. Beiko +7 more
TL;DR: Differences in functions related to host nutrition and drug pharmacology vary in an age-dependent manner, suggesting that the availability and timing of essential functions may differ significantly with age and frailty.
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A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans
Jocelyne C. Whitehead,Barbara A. Hildebrand,M. Sun,Michael R. H. Rockwood,Robert A. Rose,Kenneth Rockwood,Susan E. Howlett +6 more
TL;DR: A simplified, noninvasive method to quantify frailty through clinical assessment of C57BL/6J mice (5–28 months) and compared the relationship between FI scores and age in mice and humans was developed.
Journal ArticleDOI
A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice
Kenneth Rockwood,Joanna M Blodgett,Olga Theou,M. Sun,Hirad A. Feridooni,Arnold Mitnitski,Robert A. Rose,Judith Godin,Edward Gregson,Susan E. Howlett +9 more
TL;DR: Quantifying deficit accumulation in individual mice provides a powerful new tool that can facilitate translation of research on ageing, including in relation to disease.