Susan E. Lowe

TL;DR: Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2-4-dienoic acid, 3-hydroxy-2,4,16-trimethyl-heptadecanoic acid , sarcosine, and 3-Hydroxyasparagine.

TL;DR: During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA esters, two novel compounds, glucolipsin A and B were isolated from the butanol extracts of Streptomyces purpurogeniscleroticus and Nocardia vaccinii WC65712.

TL;DR: Orevactaene (1), a novel oxopolyene, was isolated from Epicoccum nigrum WC47880 during the screening of microbial fermentation extracts for their ability to inhibit the binding between HIV-1 regulatory protein Rev and its viral RNA-binding site, Rev response element (RRE).

TL;DR: Harziphilone and fleephilone showed inhibitory activity against the binding of REV-protein to RRE RNA with IC50 values of 2.0 microM and 7.6 microM, respectively, however both compounds did not protect CEM-SS cells from acute HIV infection at concentration levels up to 200 micrograms/ml using an XTT dye reduction assay.

TL;DR: Addition of Diaion HP-20 or Amberlite XAD-8 resin to the fermentation ofMicromonospora chersina ATCC 53710 enhanced the production of dynemicin A by 4.7- and 6.9-fold, respectively.