Susan Gilchrist

TL;DR: The intranuclear organization of chromosomes is not altered in cells that lack the integral nuclear membrane protein emerin, from an individual with X-linked Emery--Dreifuss muscular dystrophy, which suggests that emerin is not necessary for localizing chromosomes at the nuclear periphery and that the muscular Dystrophy phenotype in such individuals is not due to grossly altered nuclear organization of chromatin.

TL;DR: The data demonstrate that transcription of both ubiquitous and tissue-restricted genes is not confined to the periphery of chromosome territories, suggesting that the basal transcription machinery and transcription factors can readily gain access to the chromosome interior.

TL;DR: It is concluded that the organization of chromatin in the nucleus is not passed down precisely from one cell to its descendents but is more plastic and becomes refined during early G1, and therefore cannot be inherited from the mother nucleus.

TL;DR: This work has shown that in interphase cells chromosomes are organized in a radial distribution with the most gene-dense chromosomes toward the center of the nucleus, which facilitates cellular functions to occur in an efficient and ordered fashion.

TL;DR: The nuclear organization of histone modifications and the localization of centromeric domains in human cells before and after TSA treatment is quantified and it is concluded that the distinctive nuclear localization of 100% heterochromatin domains is independent of hist one acetylation.