Joanna M. Bridger

TL;DR: It is demonstrated that the distribution of genomic sequences between chromosomes has implications for nuclear structure and the findings are discussed in relation to a model of the human nucleus that is functionally compartmentalized.

TL;DR: The intranuclear organization of chromosomes is not altered in cells that lack the integral nuclear membrane protein emerin, from an individual with X-linked Emery--Dreifuss muscular dystrophy, which suggests that emerin is not necessary for localizing chromosomes at the nuclear periphery and that the muscular Dystrophy phenotype in such individuals is not due to grossly altered nuclear organization of chromatin.

TL;DR: It is concluded that the sub-nuclear organisation of chromosomes in quiescent or senescent mammalian somatic cells is fundamentally different from that in proliferating cells and that the spatial organisation of the genome is plastic.

TL;DR: It was determined that the unusual internal distribution of the lamin antibodies was restricted to cells in G1, and these structures were shown to be closely associated with areas of condensed chromatin but not nuclear membrane.

TL;DR: In this article, structural associations between lamin and emerin were investigated in four human cell lines displaying abnormal expression and/or localisation of lamins A and C. In each cell line absence of lamin A and c from the nuclear envelope (NE) was correlated with mis-localisation of endogenous and exogenous emerin to the ER.