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Susan M. Deneke
Researcher at Tufts Medical Center
Publications - 19
Citations - 2165
Susan M. Deneke is an academic researcher from Tufts Medical Center. The author has contributed to research in topics: Glutathione & Hyperoxia. The author has an hindex of 14, co-authored 19 publications receiving 2130 citations. Previous affiliations of Susan M. Deneke include Tufts University.
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Journal ArticleDOI
Regulation of cellular glutathione.
Susan M. Deneke,Barry L. Fanburg +1 more
TL;DR: High levels of cellular GSH levels in cultured cells in response to hyperoxia or electrophilic agents such as diethylmaleate is coupled with an increase in activity of the Xc- transport system for the amino acids cystine and glutamate.
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Interaction of oxygen and oxy-radicals with carotenoids.
TL;DR: It was concluded that carotenoid pigments function as protective agents by quenching triplet sensitizers, singlet oxygen, and radical intermediates.
Journal ArticleDOI
Normobaric oxygen toxicity of the lung
Susan M. Deneke,Barry L. Fanburg +1 more
TL;DR: Hyperbaric oxygen accelerates the effects of oxygen toxicity and also damages the central nervous system, probably because of the high partial pressure of inspired oxygen.
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Potentiation of oxygen toxicity in rats by dietary protein or amino acid deficiency
TL;DR: It is concluded that potentiation of oxygen toxicity by dietary protein deficiency in the rat is due to the low sulfur-containing amino acid content of the diet; the mechanism of increased toxicity by hyperoxia is probably related to an inability to increase glutathione levels due to a shortage of the cysteine component of the glutATHione tripeptide.
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Transient depletion of lung glutathione by diethylmaleate enhances oxygen toxicity
TL;DR: A decrease in lung GSH and related enzymes, occurring by 4 h and reversed by 12 h, has a significant effect on the subsequent progression of lung pathology and indicates that early biochemical events occurring in lungs exposed to hyperoxia may be very important in determining the degree of longer-term damage to rat lungs.