S
Susan Pav
Researcher at Boehringer Ingelheim
Publications - 21
Citations - 1930
Susan Pav is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Protease & Allosteric regulation. The author has an hindex of 15, co-authored 21 publications receiving 1878 citations.
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Journal ArticleDOI
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
Christopher Pargellis,Liang Tong,Liang Tong,L. Churchill,Pier F. Cirillo,Gilmore Thomas A,A. G. Graham,Peter M. Grob,Eugene R. Hickey,Neil Moss,Susan Pav,John R. Regan +11 more
TL;DR: A new allosteric binding site for a diaryl urea class of highly potent and selective inhibitors against human p38 MAP kinase is reported, requiring a large conformational change not observed previously for any of the protein Ser/Thr kinases.
Journal ArticleDOI
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.
Liang Tong,Susan Pav,Della White,Sheri Rogers,Kathy Crane,Charles L. Cywin,Maryanne L. Brown,Christopher Pargellis +7 more
TL;DR: The crystal structure of human p38 mitogen-activated protein (MAP) kinase in complex with a potent and highly specific pyridinyl-imidazole inhibitor has been determined at 2.0 Å resolution and reveals a possible second binding site for this inhibitor, with currently unknown function.
Journal ArticleDOI
Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction.
Kathleen Last-Barney,Walter Davidson,Mario G. Cardozo,Leah L. Frye,Christine A. Grygon,Jerry L. Hopkins,Deborah D. Jeanfavre,Susan Pav,Chungeng Qian,James M. Stevenson,Liang Tong,Renee Zindell,Terence A. Kelly +12 more
TL;DR: The binding site on the lymphocyte function-associated antigen-1 (LFA-1) of a class of hydantoin-based antagonists of leukocyte cell adhesion has been identified as mentioned in this paper.
Journal ArticleDOI
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
Journal ArticleDOI
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.
Yancey David Ward,David S. Thomson,Leah L. Frye,Charles L. Cywin,Tina Morwick,Michel J. Emmanuel,Renee Zindell,Mcneil Daniel W,Younes Bekkali,Marc Girardot,Matt Hrapchak,Molly DeTuri,Kathy Crane,Della White,Susan Pav,Yong Wang,Ming-Hong Hao,Christine A. Grygon,Mark E. Labadia,Dorothy M. Freeman,Walter Davidson,Jerry L. Hopkins,Maryanne L. Brown,Denice M. Spero +23 more
TL;DR: These inhibitors show nanomolar inhibition of the target enzyme as well as cellular potency in a human B cell line and the first X-ray crystal structure of a reversible inhibitor cocrystallized with Cathepsin S is reported.