S
Susan T. Sharfstein
Researcher at State University of New York Polytechnic Institute
Publications - 83
Citations - 2860
Susan T. Sharfstein is an academic researcher from State University of New York Polytechnic Institute. The author has contributed to research in topics: Chinese hamster ovary cell & Cell culture. The author has an hindex of 26, co-authored 76 publications receiving 2603 citations. Previous affiliations of Susan T. Sharfstein include National Institutes of Health & University of Toledo.
Papers
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Journal ArticleDOI
Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals.
Duncan C. MacLaren,Sanjiv S. Gambhir,Nagichettiar Satyamurthy,Jorge R. Barrio,Susan T. Sharfstein,Tatsushi Toyokuni,Lily Wu,Arnold J. Berk,Simon R. Cherry,M.E. Phelps,Harvey R. Herschman +10 more
TL;DR: A procedure to image reporter gene expression repetitively and non-invasively in living animals with positron emission tomography (PET), using the dopamine type 2 receptor (D2R) as a reporter gene and 3-(2′-[18F]fluoroethyl)spiperone (FESP) as the reporter probe.
Journal Article
Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir.
Sanjiv S. Gambhir,Jorge R. Barrio,Lily Wu,Meera Iyer,Mohammad Namavari,Nagichettiar Satyamurthy,Eileen Bauer,Capella Parrish,Duncan C. MacLaren,Ali R. Borghei,Leeta A. Green,Susan T. Sharfstein,Arnold J. Berk,Simon R. Cherry,Michael E. Phelps,Harvey R. Herschman +15 more
TL;DR: The feasibility of using [8-14C]-ganciclovir as a reporter probe for the HSV1-tk reporter gene, using an in vivo adenoviral mediated gene delivery system in a murine model is demonstrated.
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Heparin: Past, Present, and Future
TL;DR: A variety of strategies have been proposed to produce a bioengineered heparin including microbial production, mammalian cell production, and chemoenzymatic modification, and strategies for creating “designer” heparins and heparan-sulfates with various biochemical and physiological properties are proposed.
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An 'omics approach towards CHO cell engineering
TL;DR: This review paper discusses the recent advances in bioengineering strategies in CHO cell lines and the impact of the knowledge gained by CHO cell genomics, transcriptomics, and glycomics on the future of CHO‐cell engineering.
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Regulation of Recombinant Monoclonal Antibody Production in Chinese Hamster Ovary Cells: A Comparative Study of Gene Copy Number, mRNA Level, and Protein Expression
TL;DR: The study reveals that the MTX‐mediated MAb overexpression results from both an increase in the gene copy number and more efficient transcription of each gene copy, and the HC to LC gene copy ratio may affect the protein yield in MAb expression systems.