Susana Domingues

TL;DR: In bacteria, RNases act as a global regulatory network extremely important for the regulation of RNA levels, and intervene in the decay of many different mRNAs and small noncoding RNAs.

TL;DR: The available information on the role of bacterial 3'-5' exoribonucleases in the degradation of different substrates is summarized, highlighting the most recent data that have contributed to the understanding of the diverse modes of operation of these degradative enzymes.

TL;DR: This review gives many illustrative examples of the role of RNases in the regulation of small RNAs, and it is very important to further understand their role in the post-transcriptional control of gene expression.

TL;DR: Evidence is reported showing that around one-third of the mapped mRNAs of the major human pathogen Staphylococcus aureus carry 3′-UTRs longer than 100-nt and thus, potential regulatory functions, which provide a singular example of a new potential post-transcriptional regulatory mechanism to modulate bacterial gene expression through the interaction of a 3-UTR with the 5-utR of the same mRNA.

TL;DR: The main conclusion of this work is the existence of two independent pathways for MicA turnover, each pathway involves a distinct endoribonuclease, having a different role in the context of the fine-tuned regulation of porin levels.