Susanne Kern

TL;DR: Both UCB and AT are attractive alternatives to BM in isolating MSC: AT as it contains MSCs at the highest frequency and UCB as it seems to be expandable to higher numbers.

TL;DR: This work investigated whether cells with MSC characteristics and multi‐lineage differentiation potential can be cultivated from UCB of healthy newborns and whether yields might be maximized by optimal culture conditions or by defining UCB quality criteria.

TL;DR: It is shown that pooled human AB serum and thrombin‐activated platelet‐rich plasma are alternatives to FCS for AT‐MSCs, which are better characterized regarding potential infectious threats, while providing a higher proliferation rate and retaining differentiation capacity and mesenchymal stem cell marker expression throughout long‐term culture.

TL;DR: An autologous procedure to prepare a high concentrate from platelet-rich plasma (cPRP) for clinical application in bone regeneration is presented and a 17-fold increase in platelet concentrations was achieved compared to the patients' whole bloods and platelet counts correlated with increased levels of TGF-beta1 within the cPRP.

TL;DR: Compared MSC derived from human adult bone marrow, lipoaspirate as well as cord blood in terms of being alternatives containing high precursor frequencies and youngest adult cells, major differences were observable in the frequencies and expansion potential, whereas basic biological features were comparable.