Susanne Mandrup

TL;DR: This study uses chromatin immunoprecipitation combined with deep sequencing to generate genome-wide maps of PPARgamma and retinoid X receptor (RXR)-binding sites, and RNA polymerase II (RNAPII) occupancy at very high resolution throughout adipocyte differentiation of 3T3-L1 cells, and indicates that a hitherto unrecognized high number of adipocyte genes of distinctly regulated pathways are directly activated by PPARGamma:RxR.

TL;DR: It is now clear that multiple TFs team up to induce PPARγ during adipogenesis, and that other TFs cooperate withPPARγ to ensure adipocyte-specific genomic binding and function.

TL;DR: The function, regulation, and mechanism of the different PPAR subtypes are reviewed with special emphasis on their role in the regulation of lipid metabolism.

TL;DR: Recent contributions to the field are described and factors that probably play a role in vivo are described, including Wnt, transforming growth factor beta, inflammatory cytokines and prostaglandin F(2alpha).

TL;DR: Interestingly, these analyses show that PPARγ and C/EBPα binding sites are associated with most genes that are induced during adipogenesis suggesting direct activation of many more adipocyte genes than previously anticipated.