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Ormond A. MacDougald

Researcher at University of Michigan

Publications -  189
Citations -  27950

Ormond A. MacDougald is an academic researcher from University of Michigan. The author has contributed to research in topics: Adipose tissue & Adipogenesis. The author has an hindex of 70, co-authored 177 publications receiving 24698 citations. Previous affiliations of Ormond A. MacDougald include Johns Hopkins University & Michigan State University.

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Adipocyte differentiation from the inside out.

TL;DR: Interest in adipogenesis has increased markedly over the past few years with emphasis on the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation.
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Inhibition of Adipogenesis by Wnt Signaling

TL;DR: The authors showed that Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors CCAAT/enhancer binding protein alpha (C/EBPalpha) and peroxisome proliferator activated receptor gamma (PPARgamma).
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Regulation of bone mass by Wnt signaling

TL;DR: The current understanding of the Wnt signaling pathway in terms of bone biology is discussed and whether targeting this pathway might yield novel therapeutics to treat typical bone disorders is assessed.
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TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

TL;DR: Results show that, in addition to transcriptional activation, Wnt stimulates translation and cell growth by activating the TSC-mTOR pathway, and the sequential phosphorylation of TSC2 by AMPK and GSK3 reveals a molecular mechanism of signal integration in cell growth regulation.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.