Sergei Denissov

TL;DR: Experiments reveal crosstalk between histone modifications and the transcription factor TFIID, which has important implications for regulation of RNA polymerase II-mediated transcription in higher eukaryotes.

TL;DR: The authors' data reveal a highly adapted interplay between chromatin marks and their associated protein complexes, and reading specific trimethyl-lysine sites by specialized complexes appears to be a widespread mechanism to mediate gene expression.

TL;DR: This study uses chromatin immunoprecipitation combined with deep sequencing to generate genome-wide maps of PPARgamma and retinoid X receptor (RXR)-binding sites, and RNA polymerase II (RNAPII) occupancy at very high resolution throughout adipocyte differentiation of 3T3-L1 cells, and indicates that a hitherto unrecognized high number of adipocyte genes of distinctly regulated pathways are directly activated by PPARGamma:RxR.

TL;DR: It is shown that Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells and proposed that MLL2 is the pioneer trimethyltransferase for promoter definition in the naïve epigenome and that Polycomb group action on bivalent promoter blocks the premature establishment of active, Set1C-bound, promoters.

TL;DR: Through a DNA array-based genome-wide analysis of TCF4 chromatin occupancy, 6,868 high-confidenceTCF4-binding sites are identified in the LS174T colorectal cancer cell line and significantly correlate with Wnt-responsive gene expression profiles derived from primary human adenomas.