S
Susanne Schiffmann
Researcher at Fraunhofer Society
Publications - 76
Citations - 3391
Susanne Schiffmann is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Ceramide & Immune system. The author has an hindex of 26, co-authored 64 publications receiving 2868 citations. Previous affiliations of Susanne Schiffmann include Goethe University Frankfurt & Technische Universität München.
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Journal ArticleDOI
Cyclooxygenase-2 (COX-2)–Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors
TL;DR: The COx-2-independent molecular targets of these COX-2 inhibitors are described and it is discussed how these targets may be involved in the anticarcinogenic activities of these selective COX -2 inhibitors.
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Chain length-specific properties of ceramides.
TL;DR: The chain length-specific differences of ceramides including their pathological impact on Alzheimer's disease, inflammation, autophagy, apoptosis and cancer are discussed.
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Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
Eugen Ruckhäberle,Achim Rody,Knut Engels,Regine Gaetje,Gunter von Minckwitz,Susanne Schiffmann,Sabine Grösch,Gerd Geisslinger,Uwe Holtrich,Thomas Karn,Manfred Kaufmann +10 more
TL;DR: The correlation of SPHK1 with a poor prognosis as well as its high expression among ER negative tumors are in line with the antiapoptotic and proliferative properties of its product sphingosine-1-phosphate.
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Ceramide synthases and ceramide levels are increased in breast cancer tissue
Susanne Schiffmann,Jessica Sandner,Kerstin Birod,Ivonne Wobst,Carlo Angioni,Eugen Ruckhäberle,Manfred Kaufmann,Hanns Ackermann,Jörn Lötsch,Helmut Schmidt,Gerd Geisslinger,Sabine Grösch +11 more
TL;DR: In this paper, the authors investigated the endogenous ceramide levels in malignant breast tumors and 21 benign breast biopsies and compared them with those of normal tissues using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
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Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.
Daniela Hartmann,Jessica Lucks,Sina Fuchs,Susanne Schiffmann,Yannick Schreiber,Nerea Ferreirós,Jennifer Merkens,Rolf Marschalek,Gerd Geisslinger,Sabine Grösch +9 more
TL;DR: It is proposed that a disequilibrium between ceramides of various chain length is crucial for cancer progression, while normal cells require an equilibrium between very long and long chain ceramide for normal physiology.