G
Gerd Geisslinger
Researcher at Goethe University Frankfurt
Publications - 527
Citations - 25554
Gerd Geisslinger is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Nociception & Neuropathic pain. The author has an hindex of 77, co-authored 504 publications receiving 23176 citations. Previous affiliations of Gerd Geisslinger include University of Erlangen-Nuremberg & Fraunhofer Society.
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Cyclooxygenase-independent actions of cyclooxygenase inhibitors
TL;DR: Differences in cyclooxygenase‐independent mechanisms may have consequences for the specific use of these drugs in individual patients because additional effects may either enhance the efficacy or reduce the toxicity of the respective compounds.
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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Irmgard Tegeder,Michael Costigan,Robert S. Griffin,Andrea Abele,Inna Belfer,Helmut Schmidt,Corina Ehnert,Jemiel Nejim,Jemiel Nejim,Claudiu Marian,Joachim Scholz,Tianxia Wu,Andrew Allchorne,Luda Diatchenko,Alexander M. Binshtok,David Goldman,Jan Adolph,Swetha Sama,Steven J. Atlas,William A. Carlezon,Aram Parsegian,Jörn Lötsch,Roger B. Fillingim,William Maixner,Gerd Geisslinger,Mitchell B. Max,Clifford J. Woolf +26 more
TL;DR: It is reported that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain.
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COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib
TL;DR: In vitro and in vivo data indicate that the antitumor effects of celecoxib probably are mediated through COX‐2 independent mechanisms and are not restricted to COX•2 over‐expressing tumors.
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Cyclooxygenase-2 (COX-2)–Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors
TL;DR: The COx-2-independent molecular targets of these COX-2 inhibitors are described and it is discussed how these targets may be involved in the anticarcinogenic activities of these selective COX -2 inhibitors.
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Chain length-specific properties of ceramides.
TL;DR: The chain length-specific differences of ceramides including their pathological impact on Alzheimer's disease, inflammation, autophagy, apoptosis and cancer are discussed.