S
Suzanne L. Mansour
Researcher at University of Utah
Publications - 44
Citations - 4938
Suzanne L. Mansour is an academic researcher from University of Utah. The author has contributed to research in topics: Otic placode & Inner ear. The author has an hindex of 26, co-authored 42 publications receiving 4607 citations. Previous affiliations of Suzanne L. Mansour include Howard Hughes Medical Institute & University of California, Berkeley.
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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
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Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
TL;DR: It is concluded that even in a uniform genetic background, stochastic variation in the expression of a developmental circuit can result in dramatic differences in phenotypic consequences.
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Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins
Rolen M. Quadros,Hiromi Miura,Donald W. Harms,Hisako Akatsuka,Takehito Sato,Tomomi Aida,Tomomi Aida,Ronald Redder,Guy P. Richardson,Yutaka Inagaki,Daisuke Sakai,Shannon M. Buckley,Parthasarathy Seshacharyulu,Surinder K. Batra,Mark A. Behlke,Sarah A. Zeiner,Ashley M. Jacobi,Yayoi Izu,Wallace B. Thoreson,Lisa D. Urness,Suzanne L. Mansour,Masato Ohtsuka,Masato Ohtsuka,Channabasavaiah B. Gurumurthy +23 more
TL;DR: Easi-CRISPR solves the major problem of animal genome engineering, namely the inefficiency of targeted DNA cassette insertion, as treating an average of only 50 zygotes is sufficient to produce a correctly targeted allele in up to 100% of live offspring.
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Fgf3 and Fgf10 are required for mouse otic placode induction.
TL;DR: It is shown here that mouse Fgf10 is expressed in the mesenchyme underlying the prospective otic placode, suggesting a quantitative requirement for FGF signalling in otic vesicle formation.
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Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development.
TL;DR: It is suggested that mutations in DUSP6 or related genes are candidates for causing or modifying unexplained cases of FGFR-like syndromes, and Dusp6 mutant allele causes variably penetrant, dominant postnatal lethality, skeletal dwarfism, coronal craniosynostosis and hearing loss.