S
Suzanne M. Lohmann
Researcher at University of Würzburg
Publications - 91
Citations - 10241
Suzanne M. Lohmann is an academic researcher from University of Würzburg. The author has contributed to research in topics: Protein kinase A & cGMP-dependent protein kinase. The author has an hindex of 59, co-authored 91 publications receiving 10031 citations. Previous affiliations of Suzanne M. Lohmann include Utrecht University & French Institute of Health and Medical Research.
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Journal ArticleDOI
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action
Journal ArticleDOI
Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle
Vincent Sauzeau,Hélène Le Jeune,Chrystelle Cario-Toumaniantz,Albert Smolenski,Suzanne M. Lohmann,Jacques Bertoglio,Pierre Chardin,Pierre Pacaud,Gervaise Loirand +8 more
TL;DR: Results indicate that cGK phosphorylates and inhibits RhoA and suggest that the consequent inhibition of RHoA-induced Ca2+ sensitization and actin cytoskeleton organization contributes to the vasodilator action of nitric oxide.
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Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.
TL;DR: A dual mechanism for the inhibitory action of cyclic GMP in heart, as well as a physiological role for cGMP-PK in the control of mammalian heart function are demonstrated.
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Distinct and specific functions of cGMP-dependent protein kinases
TL;DR: The type II kinase transduces signals from the Escherichia coli heat-stable enterotoxin, STa, and from the endogenous intestinal peptide, guanylin, stimulating Cl- conductance of the cystic fibrosis transmembrane conductance regulator (CFTR).
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Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain
TL;DR: Immunohistochemical experiments demonstrate that the high concentration of immunoreactivity of the protein kinase in cerebellum is attributable to Purkinje cells, and that Immunoreactivity was found throughout the brain on smooth muscle cells of blood vessels.