S
Suzette A. Priola
Researcher at National Institutes of Health
Publications - 85
Citations - 6769
Suzette A. Priola is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Scrapie & Transmissible spongiform encephalopathy. The author has an hindex of 37, co-authored 82 publications receiving 6392 citations. Previous affiliations of Suzette A. Priola include University of California, San Diego & Scripps Research Institute.
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Journal ArticleDOI
Cell-free formation of protease-resistant prion protein
David A. Kocisko,David A. Kocisko,Jon H. Come,Jon H. Come,Suzette A. Priola,Bruce Chesebro,Gregory J. Raymond,Peter T. Lansbury,Byron Caughey +8 more
TL;DR: The conversion of PrPc to protease-resistant forms similar to PrPSc in a cell-free system composed of substantially purified constituents is reported, providing direct evidence that PrP sc derives from specific PrP c–PrPSc interactions.
Journal ArticleDOI
Anchorless prion protein results in infectious amyloid disease without clinical scrapie.
Bruce Chesebro,Bruce Chesebro,Bruce Chesebro,Matthew J. Trifilo,Matthew J. Trifilo,Matthew J. Trifilo,Richard Race,Richard Race,Richard Race,Kimberly Meade-White,Kimberly Meade-White,Kimberly Meade-White,Chao Teng,Chao Teng,Chao Teng,Rachel LaCasse,Rachel LaCasse,Rachel LaCasse,Lynne D. Raymond,Lynne D. Raymond,Lynne D. Raymond,Cynthia Favara,Cynthia Favara,Cynthia Favara,Gerald S. Baron,Gerald S. Baron,Gerald S. Baron,Suzette A. Priola,Suzette A. Priola,Suzette A. Priola,Byron Caughey,Byron Caughey,Byron Caughey,Eliezer Masliah,Eliezer Masliah,Eliezer Masliah,Michael B. A. Oldstone,Michael B. A. Oldstone,Michael B. A. Oldstone +38 more
TL;DR: In scrapie-infected transgenic mice expressing prion protein (PrP) lacking the glycosylphosphatidylinositol (GPI) membrane anchor, abnormal protease-resistant PrPres was deposited as amyloid plaques, rather than the usual nonamyloid form of PrPres, which may play a role in the pathogenesis of prion diseases.
Journal ArticleDOI
Species specificity in the cell-free conversion of prion protein to protease-resistant forms : A model for the scrapie species barrier
David A. Kocisko,Suzette A. Priola,Gregory J. Raymond,Bruce Chesebro,Peter T. Lansbury,Byron Caughey +5 more
TL;DR: It is concluded that there is species specificity in the cell-free interactions that lead to the conversion of PrPc to protease-resistant forms, which may be the molecular basis for the barriers to interspecies transmission of scrapie and other transmissible spongiform encephalopathies in vivo.
Journal ArticleDOI
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein.
Ryuichiro Atarashi,Roger A. Moore,Valerie L. Sim,Andrew G. Hughson,David W. Dorward,Henry A. Onwubiko,Suzette A. Priola,Byron Caughey +7 more
TL;DR: A much faster seeded polymerization method (rPrP-PMCA) is described which detects ≥50 ag of hamster PrPSc (≈0.003 lethal dose) within 2–3 d and should facilitate the development of rapid, ultrasensitive prion assays and diagnostic tests, in addition to aiding fundamental studies of structure and mechanism of PrP Sc formation.
Journal ArticleDOI
Porphyrin and phthalocyanine antiscrapie compounds.
TL;DR: Treatment of TSE-infected animals with three structurally dissimilar tetrapyrroles identifies these compounds as anti-TSE drugs and increases survival time from 50 to 300%.