https://cyberleninka.org/article/n/398815.pdf

Analytical techniques in pharmaceutical analysis: A review

Voltammetric Techniques for the Assay of Pharmaceuticals-a Review

Nanomaterial-modified detection systems represent a chief driver towards the adoption of electrochemical methods, since nanomaterials enable functional tunability, ability to self-assemble, and novel electrical, optical and catalytic properties that emerge at this scale. This results in tremendous gains in terms of sensitivity, selectivity and versatility. We review the electrochemical methods and mechanisms that may be applied to the detection of neurological drugs. We focus on understanding how specific nano-sized modifiers may be applied to influence the electron transfer event to result in gains in sensitivity, selectivity and versatility of the detection system. This critical review is structured on the basis of the Anatomical Therapeutic Chemical (ATC) Classification System, specifically ATC Code N (neurotransmitters). Specific sections are dedicated to the widely used electrodes based on the carbon materials, supporting electrolytes, and on electrochemical detection paradigms for neurological drugs and neurotransmitters within the groups referred to as ATC codes N01 to N07. We finally discuss emerging trends and future challenges such as the development of strategies for simultaneous detection of multiple targets with high spatial and temporal resolutions, the integration of microfluidic strategies for selective and localized analyte pre-concentration, the real-time monitoring of neurotransmitter secretions from active cell cultures under electro- and chemotactic cues, aptamer-based biosensors, and the miniaturization of the sensing system for detection in small sample volumes and for enabling cost savings due to manufacturing scale-up. The Electronic Supporting Material (ESM) includes review articles dealing with the review topic in last 40 years, as well as key properties of the analytes, viz., pKa values, half-life of drugs and their electrochemical mechanisms. The ESM also defines analytical figures of merit of the drugs and neurotransmitters. The article contains 198 references in the main manuscript and 207 references in the Electronic Supporting Material.

/pdf/nanomaterial-based-electrochemical-sensing-of-neurological-4b1gl2aqny.pdf

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

A review of the principles and application of modern electroanalytical techniques, namely, cyclic voltammetry, linear sweep voltammetry, differential pulse voltammetry, differential pulse polarography, square wave voltammetry, square wave polarography, stripping voltammetric, and stripping polarographic techniques, is presented. The use and advantages of these techniques at different electrodes are discussed. The analytical applications of these techniques to pharmaceutical compounds in dosage forms and biological media are also discussed. Various selected studies on these subjects since 1995 are reviewed.

Analysis of Pharmaceuticals and Biological Fluids Using Modern Electroanalytical Techniques

Recent developments in derivative ultraviolet/visible absorption spectrophotometry

Study of stability of methotrexate in acidic solution spectrofluorimetric determination of methotrexate in pharmaceutical preparations through acid-catalyzed degradation reaction.

Suzy M. Sabry

Papers

Study of stability of methotrexate in acidic solution spectrofluorimetric determination of methotrexate in pharmaceutical preparations through acid-catalyzed degradation reaction.

Determination of flufenamic and mefenamic acids in pharmaceutical preparations using organized media

Voltammetric, spectrofluorimetric and spectrophotometric methods to determine flufenamic acid.

Adsorptive stripping voltammetric assay of phenazopyridine hydrochloride in biological fluids and pharmaceutical preparations.

Spectrofluorimetric determination of 2-aminopyridine as a potential impurity in piroxicam and tenoxicam within the pharmacopoeial limit.