S
Sven Holger Puppel
Publications - 4
Citations - 2102
Sven Holger Puppel is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 1989 citations.
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Journal ArticleDOI
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Stefan Feske,Yousang Gwack,Murali Prakriya,Sonal Srikanth,Sven Holger Puppel,Bogdan Tanasa,Patrick G. Hogan,Richard S. Lewis,Mark J. Daly,Mark J. Daly,Anjana Rao +10 more
TL;DR: It is proposed that Orai1 is an essential component or regulator of the CRAC channel complex, which contains four putative transmembrane segments and is based on a novel protein that was identified in SCID patients.
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Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer
Carolin Schimmelpfennig,Michael Rade,Susanne Füssel,Dennis Löffler,Conny Blumert,Catharina Bertram,Angelika Borkowetz,Dominik J. Otto,Sven Holger Puppel,Pia Hönscheid,Ulrich Sommer,Gustavo B. Baretton,Ulrike Köhl,Manfred Wirth,Christian Thomas,Friedemann Horn,Markus Kreuz,Kristin Reiche +17 more
TL;DR: In this paper , the authors investigated gene fusions in prostate cancer, characterized potential novel candidates, and explored their role as prognostic markers for PCa progression, and found evidence that the number of gene fusion detected in a patient sample was significantly associated with the time to biochemical recurrence in two of the four cohorts (log-rank test, p-value < 0.05 for both cohorts).
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TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities
Christina Katharina Kuhn,Jaroslawna Meister,Sophia Kreft,Mathias Stiller,Sven Holger Puppel,Anne Zaremba,Björn Scheffler,V. Ullrich,Torsten Schöneberg,Dirk Schadendorf,Susanne Horn +10 more
TL;DR: In this article , the role of TERT expression in malignant melanoma and the non-canonical functions of the TERT remain understudied, and the authors aimed to extend the current knowledge on both types of tERT alterations with respect to survival, further clinical and molecular parameters.
Journal ArticleDOI
Database for queries of melanoma cohorts with molecular and clinical data
Manuel Philip,Sven Holger Puppel,Mathias Stiller,Annette Paschen,Alexander Roesch,Anne Zaremba,Dirk Schadendorf,Susanne Horn +7 more
TL;DR: In this paper , the authors present a new database connecting whole transcriptomes with clinical data for straight-forward access and analysis of patient-specific samples, where users can perform association tests of survival and gene expression across different cohorts, identify cell-type expressions, or correlate the presence of immune cells.