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Stefan Feske
Researcher at New York University
Publications - 125
Citations - 17220
Stefan Feske is an academic researcher from New York University. The author has contributed to research in topics: T cell & ORAI1. The author has an hindex of 55, co-authored 115 publications receiving 15178 citations. Previous affiliations of Stefan Feske include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Stefan Feske,Yousang Gwack,Murali Prakriya,Sonal Srikanth,Sven Holger Puppel,Bogdan Tanasa,Patrick G. Hogan,Richard S. Lewis,Mark J. Daly,Mark J. Daly,Anjana Rao +10 more
TL;DR: It is proposed that Orai1 is an essential component or regulator of the CRAC channel complex, which contains four putative transmembrane segments and is based on a novel protein that was identified in SCID patients.
Journal ArticleDOI
Orai1 is an essential pore subunit of the CRAC channel
TL;DR: It is shown that Orai1 is a plasma membrane protein, and that CRAC channel function is sensitive to mutation of two conserved acidic residues in the transmembrane segments, which reduces Ca2+ influx, increases current carried by monovalent cations, and renders the channel permeable to Cs+.
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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ping-Chih Ho,Jessica D. Bihuniak,Andrew N. Macintyre,Matthew M. Staron,Xiaojing Liu,Robert A. Amezquita,Yao Chen Tsui,Yao Chen Tsui,Guoliang Cui,Goran Micevic,Jose C. Perales,Steven H. Kleinstein,E. Dale Abel,Karl L. Insogna,Stefan Feske,Jason W. Locasale,Marcus Bosenberg,Jeffrey C. Rathmell,Susan M. Kaech,Susan M. Kaech +19 more
TL;DR: New metabolic checkpoints for T cell activity are uncovered and it is demonstrated that metabolic reprogramming of tumor-reactive T cells can enhance anti-tumor T cell responses, illuminating new forms of immunotherapy.
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Calcium signalling in lymphocyte activation and disease.
TL;DR: This Review focuses on the role of Ca2+ signals in lymphocyte functions, the signalling pathways leading toCa2+ influx, the function of the recently discovered regulators of Ca1+ influx (STIM and ORAI), and the relationship between Ca2- signals and diseases of the immune system.
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Gene regulation mediated by calcium signals in T lymphocytes.
TL;DR: An elaborate network of signaling pathways downstream of the T cell receptor is demonstrated, explaining the complexity of changes in gene expression during T cell activation.