S
Svetlana Markova
Researcher at University of California, San Francisco
Publications - 10
Citations - 623
Svetlana Markova is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: ATP-binding cassette transporter & Bosentan. The author has an hindex of 8, co-authored 10 publications receiving 535 citations.
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Journal ArticleDOI
Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).
Laura M. Hodges,Svetlana Markova,Leslie W. Chinn,Jason M. Gow,Deanna L. Kroetz,Teri E. Klein,Russ B. Altman +6 more
TL;DR: ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette (ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis.
Journal ArticleDOI
Attenuation of Cisplatin-Induced Renal Injury by Inhibition of Soluble Epoxide Hydrolase Involves Nuclear Factor κB Signaling
Yingmei Liu,Heather K. Webb,Hisayo Fukushima,Janine Micheli,Svetlana Markova,Jean L. Olson,Deanna L. Kroetz +6 more
TL;DR: It is suggested that EETs or other fatty acid epoxides can attenuate cisplatin-induced kidney injury and sEH inhibition is a novel renoprotective strategy.
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Association of CYP2C9*2 with bosentan-induced liver injury.
Svetlana Markova,T. De Marco,Nasrine Bendjilali,Erin Kobashigawa,Joel Mefford,Jasleen K. Sodhi,Hoa Le,Chenghong Zhang,Jason Halladay,Allan E. Rettie,S. Cyrus Khojasteh,Dana McGlothlin,Alan H.B. Wu,W. C. Hsueh,John S. Witte,Janice B. Schwartz,Deanna L. Kroetz +16 more
TL;DR: It is suggested that CYP2C9*2 is a potential genetic marker for prediction of bosentan‐induced liver injury and warrants investigation for the optimization of bosENTan treatment.
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ABCC4 is regulated by microRNA-124a and microRNA-506
TL;DR: Regulation of ABCC4 by miRNAs represents a novel mechanism for regulation of MRP4 function and polymorphisms in theABCC4 3'-UTR have no significant effect on this miRNA regulation.
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Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression.
Tan D. Nguyen,Svetlana Markova,Wanqing Liu,Jason M. Gow,R. M. Baldwin,M Habashian,Mary V. Relling,Mark J. Ratain,Deanna L. Kroetz +8 more
TL;DR: Investigation of the functional significance of promoter region polymorphisms in ABCC2 and potential allele-specific expression found that Luciferase reporter gene assays showed thatABCC2 −24C>T both alone and as part of a common haplotype increased promoter function 35% compared with the reference sequence.