S
Svetlana Sadekova
Researcher at Merck & Co.
Publications - 31
Citations - 3826
Svetlana Sadekova is an academic researcher from Merck & Co.. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 16, co-authored 29 publications receiving 3361 citations. Previous affiliations of Svetlana Sadekova include McGill University Health Centre & Schering-Plough.
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Journal ArticleDOI
Stromal gene expression predicts clinical outcome in breast cancer
Greg Finak,Nicholas Bertos,Francois Pepin,Francois Pepin,Svetlana Sadekova,Margarita Souleimanova,Hong Zhao,Haiying Chen,Gulbeyaz Omeroglu,Sarkis Meterissian,Atilla Omeroglu,Michael Hallett,Morag Park,Morag Park +13 more
TL;DR: Genes represented in the new stroma-derived prognostic predictor (SDPP) reveal the strong prognostic capacity of differential immune responses as well as angiogenic and hypoxic responses, highlighting the importance of stromal biology in tumor progression.
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Multiplexed quantification of proteins and transcripts in single cells
Vanessa M. Peterson,Kelvin Xi Zhang,Namit Kumar,Jerelyn Wong,Lixia Li,Douglas C. Wilson,Renee Moore,Terrill K. McClanahan,Svetlana Sadekova,Joel A. Klappenbach +9 more
TL;DR: Using the RNA expression and protein sequencing assay (REAP-seq), the costimulatory effects of a CD27 agonist on human CD8+ lymphocytes and to identify and characterize an unknown cell type are assessed.
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Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
Melanie A. Kleinschek,Katia Boniface,Svetlana Sadekova,Jeff Grein,Erin Murphy,Scott P. Turner,Lisa Raskin,Bela Desai,William A. Faubion,Rene de Waal Malefyt,Robert H. Pierce,Terrill K. McClanahan,Robert A. Kastelein +12 more
TL;DR: The data identify CD161+ CD4 T cells as a resting Th17 pool that can be activated by IL-23 and mediate destructive tissue inflammation.
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Human Th17 Cells Comprise Heterogeneous Subsets Including IFN-γ–Producing Cells with Distinct Properties from the Th1 Lineage
Katia Boniface,Wendy M. Blumenschein,Katherine Brovont-Porth,Mandy J. McGeachy,Beth Basham,Bela Desai,Robert H. Pierce,Terrill K. McClanahan,Svetlana Sadekova,Rene de Waal Malefyt +9 more
TL;DR: It is shown that not only IL-17+/IFN-γ+ but also IFN-β+ (IL-17−) cells arise under Th17-inducing condition and have distinct properties from the Th1 lineage, and these Th17 subsets became “Th1-like” cells in the presence of IL-12.
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Gene expression signatures of morphologically normal breast tissue identify basal-like tumors.
Greg Finak,Greg Finak,Svetlana Sadekova,Svetlana Sadekova,Francois Pepin,Francois Pepin,Michael Hallett,Sarkis Meterissian,Fawaz Halwani,Karim Khetani,Margarita Souleimanova,Brent P. Zabolotny,Atilla Omeroglu,Morag Park +13 more
TL;DR: The data reveal that morphologically normal tissue adjacent to breast carcinomas has not undergone significant gene expression changes when compared to breast reduction tissue, and provide an important gene expression dataset for comparative studies of tumor expression profiles.