S
Swapnil Sinha
Researcher at DST Systems
Publications - 2
Citations - 65
Swapnil Sinha is an academic researcher from DST Systems. The author has contributed to research in topics: Chronic stress & Corticosterone. The author has an hindex of 2, co-authored 2 publications receiving 43 citations.
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Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice.
TL;DR: The antidepressant‐like ability of drug treatments against chronic CORT induced stress model, as revealed in this study, may be due to their potential to mitigate inflammatory damage and oxidative stress via modulation of hippocampal NF‐&kgr;B p65, COX‐2, HDAC2 and phosphorylated JNK levels.
Journal ArticleDOI
Cognitive Improvement by Vorinostat through Modulation of Endoplasmic Reticulum Stress in a Corticosterone-Induced Chronic Stress Model in Mice.
Athira K,Rajaram Mohanrao Madhana,Akhilesh Kumar Bais,Vijay Bahadur Singh,Arpit Malik,Swapnil Sinha,Mangala Lahkar,Pramod Kumar,Pavan Kumar Samudrala +8 more
TL;DR: VOR has the potential to reverse cognitive dysfunction via modulation of ER stress markers and HDAC2 and reversed CORT induced rise in HDac2 level in the CA3 region.