M
Mangala Lahkar
Researcher at Gauhati Medical College and Hospital
Publications - 99
Citations - 2619
Mangala Lahkar is an academic researcher from Gauhati Medical College and Hospital. The author has contributed to research in topics: Oxidative stress & Tail suspension test. The author has an hindex of 26, co-authored 97 publications receiving 1977 citations. Previous affiliations of Mangala Lahkar include Assam Agricultural University & Department of Biotechnology.
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Journal ArticleDOI
Therapeutic targets of triple‐negative breast cancer: a review
Vinayak S. Jamdade,Nikunj Sethi,Nikunj Sethi,Nitin A Mundhe,Parveen Kumar,Mangala Lahkar,Neeraj Sinha,Neeraj Sinha +7 more
TL;DR: This review presents recent information associated with different therapeutic options for the treatment of TNBC focusing on promising targets such as the Notch signalling, Wnt/β‐catenin and Hedgehog pathways, in addition to EGFR, PARP1, mTOR, TGF‐β and angiogenesis inhibitors.
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Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice.
Syed Hamid Ali,Rajaram Mohanrao Madhana,Athira K,Eshvendar Reddy Kasala,Lakshmi Narendra Bodduluru,Sathish Pitta,Jalandhar Reddy Mahareddy,Mangala Lahkar +7 more
TL;DR: The results suggest that resveratrol produces an antidepressant-like effect in CORT-induced depression in mice, which is possibly mediated by rectifying the stress-based hypothalamic-pituitary-adrenal (HPA) axis dysfunction paradigm and upregulation of hippocampal BDNF levels.
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Lipopolysaccharide induced anxiety- and depressive-like behaviour in mice are prevented by chronic pre-treatment of esculetin.
Kunjbihari Sulakhiya,Gohil Pratik Keshavlal,Babul B. Bezbaruah,Shubham Dwivedi,Satendra Singh Gurjar,Nitin Munde,Ashok Jangra,Mangala Lahkar,Ranadeep Gogoi +8 more
TL;DR: The results suggest that ESC prevented LPS-induced anxiety- and depressive-like behaviour which may be governed by inhibition of cytokine production, oxidative stress and plasma CORT level and the potential usefulness of ESC in the treatment of psychiatric disorders associated with inflammation and oxidative stress.
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Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice.
TL;DR: It is demonstrated that mangiferin possessed antidepressant and anti-anxiety properties due to its ability to attenuate IL-1β level and oxidative stress evoked by intraperitoneal administration of lipopolysaccharide.
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Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice.
Kunjbihari Sulakhiya,Parveen Kumar,Ashok Jangra,Shubham Dwivedi,Naba K. Hazarika,Chandana C. Baruah,Mangala Lahkar +6 more
TL;DR: It is suggested that HNK pretreatment provided protection against LPS-induced depressive like behavior which may be mediated by repression of pro-inflammatory cytokines as well as oxido-nitrosative stress in HC and PFC.