S
Syamal Roy
Researcher at Indian Institute of Chemical Biology
Publications - 119
Citations - 4292
Syamal Roy is an academic researcher from Indian Institute of Chemical Biology. The author has contributed to research in topics: Leishmania donovani & Visceral leishmaniasis. The author has an hindex of 34, co-authored 111 publications receiving 3679 citations. Previous affiliations of Syamal Roy include Massachusetts Institute of Technology & Council of Scientific and Industrial Research.
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Use of antimony in the treatment of leishmaniasis: current status and future directions.
TL;DR: It has been shown that some of the peroxovanadium compounds have Sb(V)-resistance modifying ability in experimental infection with Sb (V) resistant Leishmania donovani isolates in murine model, and vanadium compounds may be used in combination with S b(V) in the treatment of Sb.(V) resistance cases of kala-azar.
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Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis.
TL;DR: This is the first report of a vaccine conferring protection to both antimony responsive and resistant Leishmania strains reflecting several aspects of clinical visceral leishmaniasis.
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Sodium Antimony Gluconate Induces Generation of Reactive Oxygen Species and Nitric Oxide via Phosphoinositide 3-Kinase and Mitogen-Activated Protein Kinase Activation in Leishmania donovani-Infected Macrophages
Jayati Mookerjee Basu,Ananda Mookerjee,Prosenjit Sen,Suniti Bhaumik,Pradip Sen,Subha Banerjee,Kshudiram Naskar,Soumitra Kumar Choudhuri,Bhaskar Saha,Sanghamitra Raha,Syamal Roy +10 more
TL;DR: This study has provided the first evidence that SAG treatment induces activation of some important components of the intracellular signaling pathway, which results in an early wave of ROS- dependent parasite killing and a stronger late wave of NO-dependent parasite killing.
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Leishmania donovani Targets Dicer1 to Downregulate miR-122, Lower Serum Cholesterol, and Facilitate Murine Liver Infection
TL;DR: Restoration of miR-122 or Dicer1 levels in VL mouse liver increased serum cholesterol and reduced liver parasite burden and altered expression of lipid metabolic genes, many of which are direct or indirect targets of the liver-specific microRNA-122.
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Leishmania donovani suppresses activated protein 1 and NF-κB activation in host macrophages via ceramide generation: involvement of extracellular signal-regulated kinase
Sanjukta Ghosh,Sandip Bhattacharyya,Madhumita Sirkar,Gouri Shankar Sa,Tanya Das,Debashis Majumdar,Syamal Roy,Subrata Majumdar +7 more
TL;DR: The induction of ceramide synthesis in host macrophages appears to be instrumental and one of the turning points leading to silencing of the macrophage antileishmanial responses.