S
Sydney I. Ramirez
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 26
Citations - 10791
Sydney I. Ramirez is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Medicine & T cell. The author has an hindex of 13, co-authored 21 publications receiving 5545 citations. Previous affiliations of Sydney I. Ramirez include University of California, San Diego & University of Texas Medical Branch.
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Journal ArticleDOI
Development of a novel, single-cycle replicable rift valley Fever vaccine.
TL;DR: A novel, single-cycle replicable MP-12 (scMP-12), which carries an L RNA, M RNA mutant encoding a mutant envelope protein lacking an endoplasmic reticulum retrieval signal and defective for membrane fusion function, and S RNA encoding N protein and green fluorescent protein is developed.
Journal ArticleDOI
Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status
Esther Dawen Yu,Eric Wang,Emily Garrigan,Benjamin Goodwin,Aaron Sutherland,Alison Tarke,James Chang,Rosa Isela Gálvez,Jose Mateus,Sydney I. Ramirez,Stephen A. Rawlings,Davey M. Smith,Gilberto Filaci,April Frazier,Daniela Weiskopf,Jennifer M. Dan,Shane Crotty,Alba Grifoni,Alessandro Sette,Ricardo da Silva Antunes +19 more
TL;DR: In this paper , the authors developed two pools of experimentally defined SARS-CoV-2 T cell epitopes that, in combination with spike, were used to discriminate 4 groups of subjects with different SARS CoV2 infection and COVID-19 vaccine status, with a combined performance of 86.6% across all 239 subjects from the 5 groups.
Posted ContentDOI
AI-guided discovery of the invariant host response to viral pandemics
Debashis Sahoo,Gajanan D. Katkar,Soni Khandelwal,Mahdi Behroozikhah,Amanraj Claire,Vanessa Castillo,Courtney Tindle,MacKenzie Fuller,Sahar Taheri,Thomas F. Rogers,Thomas F. Rogers,Nathan Beutler,Sydney I. Ramirez,Sydney I. Ramirez,Stephen A. Rawlings,Victor Pretorius,David M. Smith,Dennis R. Burton,Laura E. Crotty Alexander,Jason M. Duran,Shane Crotty,Shane Crotty,Jennifer M. Dan,Jennifer M. Dan,Soumita Das,Pradipta Ghosh +25 more
TL;DR: The host immune response is defined using an AI-based approach and a signature that is surprisingly conserved in all viral pandemics, including Covid-19, inspiring the nomenclature ViP-signature is identified.
Journal ArticleDOI
Mechanistic Insight into the Host Transcription Inhibition Function of Rift Valley Fever Virus NSs and Its Importance in Virulence
TL;DR: The study results lead to suggest that the ability of NSs to induce p62 degradation is the major contributor to its general transcription inhibition property, whereas its interaction with p44 may not play a significant role in this function.
Posted ContentDOI
Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients
Jorge A. Masso-Silva,Jorge A. Masso-Silva,Alexander Moshensky Bs,Alexander Moshensky Bs,Michael T. Lam,Michael T. Lam,Mazen Odish,Arjun Patel Mbbs,Arjun Patel Mbbs,Le Xu,Emily Hansen Ms,Samantha Trescott Bs,Celina Nguyen Bs,Roy Kim Bs,Katherine Perofsky,Samantha Perera N,Samantha Perera N,Lauren Ma Bs,Lauren Ma Bs,Josephine Pham N,Mark Rolfsen,Jarod Olay Ms,John Shin Bs,Jennifer M. Dan,Robert K. Abbott,Sydney I. Ramirez,Thomas H. Alexander Md MHSc,Thomas H. Alexander Md MHSc,Grace Y. Lin,Ana Lucia Fuentes,Ana Lucia Fuentes,Ira N. Advani Bs,Deepti Gunge Bs,Victor Pretorius MBChB,Atul Malhotra,Xin Sun,Jason M. Duran,Shane Crotty,Nicole G. Coufal,Angela Meier,Laura E. Crotty Alexander,Laura E. Crotty Alexander +41 more
TL;DR: In this paper, neutrophils in COVID-19 patients exhibited an activated phenotype with increased oxidative burst, extracellular trap formation (NETosis), phagocytosis and cytokine levels.