N
Nathan Beutler
Researcher at Scripps Research Institute
Publications - 39
Citations - 3648
Nathan Beutler is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Coronavirus & Antibody. The author has an hindex of 15, co-authored 27 publications receiving 2052 citations. Previous affiliations of Nathan Beutler include International AIDS Vaccine Initiative.
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Journal ArticleDOI
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
Thomas F. Rogers,Thomas F. Rogers,Fangzhu Zhao,Deli Huang,Nathan Beutler,Alison Burns,Wan-ting He,Oliver Limbo,Oliver Limbo,Chloe Smith,Ge Song,Jordan L. Woehl,Jordan L. Woehl,Linlin Yang,Robert K. Abbott,Robert K. Abbott,Sean Callaghan,Elijah Garcia,Jonathan Hurtado,Mara Parren,Linghang Peng,Sydney I. Ramirez,James Ricketts,Michael J. Ricciardi,Stephen A. Rawlings,Nicholas C. Wu,Meng Yuan,Davey M. Smith,David Nemazee,John R. Teijaro,James E. Voss,Ian A. Wilson,Raiees Andrabi,Bryan Briney,Elise Landais,Devin Sok,Joseph G. Jardine,Joseph G. Jardine,Dennis R. Burton +38 more
TL;DR: A role for potent neutralizing antibodies (nAbs) in prophylaxis, and potentially therapy, of COVID-19 is suggested, as indicated by maintained weight and low lung viral titers in treated animals, and the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters.
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Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples
Joshua Quick,Nathan D. Grubaugh,Steven T. Pullan,Ingra Morales Claro,Andrew D. Smith,Karthik Gangavarapu,Glenn Oliveira,Refugio Robles-Sikisaka,Thomas F. Rogers,Thomas F. Rogers,Nathan Beutler,Dennis R. Burton,Lia Laura Lewis-Ximenez,Jaqueline Goes de Jesus,Marta Giovanetti,Marta Giovanetti,Sarah C. Hill,Allison Black,Allison Black,Trevor Bedford,Miles W. Carroll,Márcio Roberto Teixeira Nunes,Luiz Carlos Junior Alcantara,Ester Cerdeira Sabino,Sally A. Baylis,Nuno R. Faria,Matthew Loose,Jared T. Simpson,Oliver G. Pybus,Kristian G. Andersen,Kristian G. Andersen,Nicholas J. Loman +31 more
TL;DR: A protocol for generating coding-sequence-complete genomes, comprising an online primer design tool, a novel multiplex PCR enrichment protocol, optimized library preparation methods for the portable MinION sequencer and the Illumina range of instruments, and a bioinformatics pipeline for generating consensus sequences.
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Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection.
Ge Song,Wan ting He,Sean Callaghan,Fabio Anzanello,Deli Huang,James Ricketts,Jonathan L. Torres,Nathan Beutler,Linghang Peng,Sirena Vargas,Jon Cassell,Mara Parren,Linlin Yang,Caroline Ignacio,Davey M. Smith,James E. Voss,David Nemazee,Andrew B. Ward,Thomas F. Rogers,Thomas F. Rogers,Dennis R. Burton,Raiees Andrabi +21 more
TL;DR: In this paper, the authors compare serum antibody and memory B cell responses to coronavirus spike proteins from pre-pandemic and SARS-CoV-2 convalescent donors using binding and functional assays.
Journal ArticleDOI
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Britton Boras,Rhys M. Jones,Brandon J. Anson,Dan Arenson,Lisa Aschenbrenner,Malina A. Bakowski,Nathan Beutler,Joseph John Binder,Emily I. Chen,Heather Eng,Holly L. Hammond,Jennifer Hammond,Robert Haupt,Robert M. Hoffman,Eugene P. Kadar,Rob Kania,Emi Kimoto,Melanie G. Kirkpatrick,Lorraine F. Lanyon,Emma K. Lendy,Lillis Jonathan Richard,James Logue,Suman Luthra,Chunlong Ma,Stephen W. Mason,Marisa McGrath,Stephen Noell,R. Scott Obach,Matthew N O' Brien,Rebecca E. O’Connor,Kevin Ogilvie,Dafydd R. Owen,Martin Pettersson,Matthew R. Reese,Thomas F. Rogers,Thomas F. Rogers,Romel Rosales,Michelle Rossulek,Jean G. Sathish,Norimitsu Shirai,Claire M. Steppan,Martyn D. Ticehurst,Lawrence W. Updyke,Stuart Weston,Yuao Zhu,Kris M. White,Adolfo García-Sastre,Jun Wang,Arnab K. Chatterjee,Andrew D. Mesecar,Matthew B. Frieman,Annaliesa S. Anderson,Charlotte Moira Norfor Allerton +52 more
TL;DR: In this paper, a phosphate prodrug PF-07304814 was developed to inhibit coronavirus family 3CL protease activity with selectivity over human host protease targets.
Journal ArticleDOI
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
Panpan Zhou,Meng Yuan,Ge Song,Nathan Beutler,Namir Shaabani,Deli Huang,Wan-ting He,Xu-Dong Zhu,Sean Callaghan,Peter Yong,Fabio Anzanello,Linghang Peng,James Ricketts,Mara Parren,Elijah Garcia,Stephen A. Rawlings,Davey M. Smith,David Nemazee,John R. Teijaro,Thomas F. Rogers,Ian A. Wilson,Dennis R. Burton,Raiees Andrabi +22 more
TL;DR: The authors identified a human monoclonal antibody isolated from a convalescent donor, CC40.8, that bound to the SARS-CoV-2 S2 stem peptide, a region that is conserved across beta-coronaviruses.