S
Sylvie Thirion
Researcher at Centre national de la recherche scientifique
Publications - 31
Citations - 1826
Sylvie Thirion is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Somatostatin & Prostaglandin E. The author has an hindex of 19, co-authored 30 publications receiving 1641 citations. Previous affiliations of Sylvie Thirion include Mediterranean University & Université Paul Cézanne Aix-Marseille III.
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Journal ArticleDOI
Primary culture and phenotyping of murine chondrocytes
TL;DR: This protocol, involving primary cultures to limit dedifferentiation, describes two different methods for culturing chondrocytes of different anatomical origins (articular and costal chondROcytes, both of which represent hyaline cartilage) from mice.
Journal ArticleDOI
Prostaglandins and sickness behavior: old story, new insights.
TL;DR: This review takes stock of previous knowledge and recent advances in understanding the role of prostaglandins and of their specific synthesizing enzymes in the molecular mechanisms underlying sickness behavior and points out therapeutic developments in this research field.
Journal ArticleDOI
Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene
Marjolaine Gosset,Francis Berenbaum,Arlette Levy,A. Pigenet,Sylvie Thirion,Jean-Louis Saffar,Claire Jacques +6 more
TL;DR: Investigation of the regulation of the genes encoding COX and PGES isoforms during mechanical stress applied to cartilage explants concluded that, along with COX-2, dynamic compression induces mPGES-1 mRNA and protein expression in cartilageExplants and represents a potential therapeutic target in osteoarthritis.
Book ChapterDOI
Culture and phenotyping of chondrocytes in primary culture.
Sylvie Thirion,Francis Berenbaum +1 more
TL;DR: This chapter describes several protocols for culturing chondrocytes of different anatomical origins from various species (humans, mice, rabbits, and cattle) and involves primary cultures in order to limit dedifferentiation.
Journal ArticleDOI
Concomitant Recruitment of ERK1/2 and p38 MAPK Signalling Pathway Is Required for Activation of Cytoplasmic Phospholipase A2via ATP in Articular Chondrocytes *
TL;DR: The results suggest that PGE2 production induced by ATP requires the activation of both ERK1/2 and p38 MAPKs, which suggests that ATP acts via P2Y2-purine receptors to recruit cPLA2 by activating both ERk1/1 and p 38 MAPks and stimulates the release of PGE 2 from articular chondrocytes.