T. A. Kalinina

TL;DR: To contribute molecular diversity for novel fungicide development, a series of novel thiazole carboxamides were rationally designed, synthesized, and characterized with the succinate dehydrogenase (SDH) as target to show promising in vitro fungicidal activities against R. cerealis and S. sclerotiorum.

TL;DR: In vitro bioassay indicated that compound 5i was outstood with broad-spectrum of in vitro activity against five fungi, and in vivo fungicidal activity of 5i exhibited excellent inhibitory rate against Puccinia sorghi and R. solani, and Fluorescence quenching analysis and SDH enzymatic inhibition studies validated its mode of action.

TL;DR: It is demonstrated that 2,4,5-trioxopyrrolidin-1,3-thiazolidine derivatives exhibited a relatively broad spectrum of antifungal activity and is a promising fungicidal candidate for plant protection.

TL;DR: In this article, a series of novel tetrazole containing 1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction and their structures were confirmed by melting points, IR, 1H NMR, and HRMS (ESI).

TL;DR: The expression of the systemic acquired resistance gene pr1 was significantly up-regulated after treating with compound 6u for 24 h and 48 h (122-fold) and can help the development of isothiazole–thiazole-based novel fungicides.