Showing papers by "T. M. Sridhar published in 2022"
TL;DR: In this article , conductivity and dielectric constant were optimized for the production of thin fiber and bead free nanofibrous mat for bone regeneration applications, which can be deployed as an ideal material for bone regenerative applications.
Abstract: The research on extracellular matrix (ECM) is new and developing area that covers cell proliferation and differentiation and ensures improved cell viability for different biomedical applications. Extracellular matrix not only maintains biological functions but also exhibits properties such as tuned or natural material degradation within a given time period, active cell binding and cellular uptake for tissue engineering applications. The principal objective of this study is classified into two categories. The first phase is optimization of various electrospinning parameters with different concentrations of HAP-HPC/PLA(hydroxyapatite-hydroxypropylcellulose/poly lactic acid). The second phase is in vitro biological evaluation of the optimized mat using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay for bone regeneration applications. Conductivity and dielectric constant were optimized for the production of thin fiber and bead free nanofibrous mat. With this optimization, the mechanical strength of all compositions was found to be enhanced, of which the ratio of 70:30 hit a maximum of 9.53 MPa (megapascal). Cytotoxicity analysis was completed for all the compositions on MG63 cell lines for various durations and showed maximum cell viability on 70:30 composition for more than 48 hrs. Hence, this investigation concludes that the optimized nanofibrous mat can be deployed as an ideal material for bone regenerative applications. In vivo study confirms the HAP-HPC-PLA sample shows more cells and bone formation at 8 weeks than 4 weeks.
2 citations
TL;DR: In this paper , the development of biocompatible nano zirconia, nano Yttria stabilised Zirconium (YSZ) and nano YSZ/Chitosan (nano biocomposite) coatings on 316L stainless steel (316L SS) were reported by Electrophoretic deposition and dip coating process along with the and the samples sintered at air atmosphere.
Abstract: Significant impact in dental industry was development of biocompatible dental implants has become, In the present work, here, the development of biocompatible nano zirconia, nano Yttria stabilised Zirconia (YSZ) and nano YSZ/Chitosan (nano biocomposite) coatings on 316L stainless steel (316L SS) were reported by Electrophoretic deposition and dip coating process along with the and the samples sintered at air atmosphere. The surface morphology and composition of the coated samples were investigated by using XRD, Raman, AFM and FE-SEM with EDAX respectively. The various electrochemical techniques were performed for the coated and uncoated samples.
31 Oct 2022
TL;DR: In this paper , multivariate statistical methods such as Principal Component Analysis/Factor analysis (PCA/FA), and Cluster Analysis (CA) were used to characterize spatial and temporal variations and to find out the pollution source of 11 lakes of the Kancheepuram district, a northeast district of Tamilnadu in India.
Abstract: Multivariate statistical methods such as Principal Component Analysis/Factor analysis (PCA/FA), and Cluster Analysis (CA) were used to characterize spatial and temporal variations and to find out the pollution source of 11 lakes of the Kancheepuram district, a northeast district of Tamilnadu in India. Sampling events were conducted during the northeast monsoon (Dec 2015 & 2016) and Pre-monsoon (Oct 2016). The 20 physicochemical water quality parameters were used to analyze the collected water samples.In PCA, four components were demonstrated up to 73.12% of the total variance in the data set. It clarifies that variations in water quality parameters concentration are mainly identified with agricultural, industrial, domestic wastes, and natural factors. The CA showed the formation of three clusters based on the water quality variation at different locations. From the CA data, sampling sites were classified into high, moderate, and least polluted. Among these sites, Kolavai, Nattapettai and Uthiramerur were highly polluted because of rapid urbanization and industrialization. Therefore, these areas need some effective measures to enhance the quality of water.