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T. R. Hennessy
Researcher at St Thomas' Hospital
Publications - 8
Citations - 642
T. R. Hennessy is an academic researcher from St Thomas' Hospital. The author has contributed to research in topics: Insulin & Very low-density lipoprotein. The author has an hindex of 8, co-authored 8 publications receiving 631 citations. Previous affiliations of T. R. Hennessy include Hammersmith Hospital.
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Journal ArticleDOI
Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in NIDDM.
M.H. Cummings,Gerald F. Watts,Anne Umpleby,T. R. Hennessy,Rossitza P. Naoumova,B.M. Slavin,Gilbert R. Thompson,Peter H. Sönksen +7 more
TL;DR: There is increased hepatic secretion of VLDL apoB which may partly explain the dyslipoproteinaemia seen in the non-insulin-dependent diabetes mellitus (NIDDM), and it is suggested that increased secretion of this apolipoprotein may be a consequence of resistance to the inhibitory effect of insulin.
Journal ArticleDOI
Use of a leucine clamp to demonstrate that IGF-I actively stimulates protein synthesis in normal humans.
David Russell-Jones,A. M. Umpleby,T. R. Hennessy,S. B. Bowes,Fariba Shojaee-Moradie,K. D. Hopkins,Nicola Jackson,J.M. Kelly,Richard H. Jones,Peter H. Sönksen +9 more
TL;DR: It is concluded that IGF-I, under conditions of adequate substrate supply, directly increases protein synthesis in contrast to insulin, which exerts its anabolic action by reducing proteolysis.
Journal ArticleDOI
Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in obesity: a stable isotope study.
M.H. Cummings,Gerald F. Watts,Cauvery Pal,Margot Umpleby,T. R. Hennessy,Rossitza P. Naoumova,Peter H. Sönksen +6 more
TL;DR: Plasma total cholesterol, triacylglycerol and mevalonic acid (an index of cholesterol synthesis in vivo) concentrations were significantly higher in the obese subjects than in control subjects, but there was no significant difference in the fractional catabolic rate of VLDL apoB.
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A comparison of the effects of IGF-I and insulin on glucose metabolism, fat metabolism and the cardiovascular system in normal human volunteers
DL Russell-Jones,Andrew Bates,Anne Umpleby,T. R. Hennessy,S B Bowes,K. D. Hopkins,Nicola Jackson,J. M. Kelly,Fariba Shojaee-Moradie,Richard H. Jones +9 more
TL;DR: There was no change in free fatty acids (FFA) and an increase (percentage change from pre‐infusion mean) in cardiac output, heart rate, and stroke volume and there were no significant changes in the cardiovascular variables.
Journal ArticleDOI
Acute Hyperinsulinemia Decreases the Hepatic Secretion of Very-Low-Density Lipoprotein Apolipoprotein B-100 in NIDDM
M.H. Cummings,Gerald F. Watts,Anne Umpleby,T. R. Hennessy,J.M. Kelly,Nicola Jackson,Peter H. Sönksen +6 more
TL;DR: It is concluded that acute hyperinsulinemia decreases the hepatic secretion rate of VLDL apoB in NIDDM, probably in part due to reduction in the delivery of NEFA and glycerol substrate to the liver.