T
T. R. Santhosh Kumar
Researcher at Rajiv Gandhi Centre for Biotechnology
Publications - 34
Citations - 1016
T. R. Santhosh Kumar is an academic researcher from Rajiv Gandhi Centre for Biotechnology. The author has contributed to research in topics: Cancer stem cell & Cancer cell. The author has an hindex of 13, co-authored 28 publications receiving 779 citations. Previous affiliations of T. R. Santhosh Kumar include Manipal University.
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Induction of Apoptosis by Curcumin and Its Implications for Cancer Therapy
TL;DR: This review describes the mechanisms of curcumin-induced apoptosis currently known, and suggests several potential strategies that include down-regulation of antiapoptotic proteins by antisense oligonucleotides, use of proAPoptotic peptides and combination therapy, and other novel approaches against chemoresistant tumors.
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Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases.
TL;DR: In this paper, mild heat treatment induced the expression of heat shock protein-70 (hsp70), hsp90 and hsp27 in two human colon cancer cell lines, one derived from primary tumor, SW480, and the other derived from the secondary lymph node tissue, SW620, of the same patient.
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Side population cells as prototype of chemoresistant, tumor-initiating cells.
TL;DR: This review intends to appraise the experimental progress towards enhanced isolation and drug screening based on property of acquired chemoresistance of cancer stem cells.
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Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors.
TL;DR: The study identified two citrus fruit flavonoids, NG and HP, as HER2-TK inhibitors and this is the first report on their potential to target preferentially and sensitize HER2 positive cancer cells to cell death.
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Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide.
TL;DR: It is demonstrated that reactive oxygen species generated by TBHP decreased markedly in the L6 cells on preincubation with flavonoids in a dose-dependent manner and remarkably retrieved the glutathione level which was drastically decreased on oxidative challenge.